血清PRL水平与MRI扫描垂体催乳素瘤的对比分析及临床应用
Comparative Analysis and Clinical Application of Serum PRL and MRI Scan on Pituitary Prolactinoma
朱梅 1张勇 2彭虹 2邱红 3袁鹏 3阮书平1
作者信息
- 1. 湖北医药学院附属东风医院,核医学科,442008
- 2. 湖北医药学院附属东风医院,影像科,442008
- 3. 湖北医药学院附属东风医院,检验科,442008
- 折叠
摘要
目的:通过血清催乳素(PRL)含量与MRI扫描垂体催乳素瘤的对照研究,观察垂体催乳素瘤的特征,可进一步评价垂体催乳素瘤的生物学行为.方法:搜集确诊垂体催乳素瘤患者66例,同时行垂体MRI常规序列扫描及同位增强扫描.结果:微腺瘤患者中女性多见;好发在垂体前叶后部两侧.大腺瘤患者中男性多见;性腺功能减低发生率高;侵袭性腺瘤发生率高、复发率高.催乳素瘤的大小与血清PRL水平呈直线相关性(r=0.4372,P＜0.01).结论:血清PRL增高,结合MRI动态增强扫描可准确显示垂体催乳素瘤的形态及位置,对照研究可初步评估肿瘤的生物学行为,为临床诊断治疗提供重要依据.
Abstract
Objective Through the serum prolactin level and MRI scan pituitary prolactinoma case-control study,observation of pituitary prolactin-secreting tumor characteristics,further evaluation of pituitary prolactinoma biological behavior.Methods To collect the undiagnosed pituitary prolactinoma patients 66 cases,at the same time of pituitary MRI routine sequence scanning and parity enhanced scan.Results Microadenoma of most of the patients were females,occurred in the anterior pituitary of the two side of the back.Large adenomas in patients with male gonadal dysfunction;High incidence of invasive adenomas;high incidence rate,high recurrence rate.Prolactin-secreting tumor size and serum level of PRL showed a linear correlation(r=0.4372,P<0.01).Conclusion Serum PRL increased,combining with dynamic enhanced MRI scan can accurately display the PRL of pituitary prolactinoma shape and position,casecontrol study preliminary assessment of tumor biological behavior,and provide important basis for clinical diagnosis and treatment.
关键词
催乳素/垂体肿瘤/磁共振成像/生物学Key words
prolactin/pituitary/magnetic resonance imaging/biology引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据