消化性溃疡患者血清IL-2、IL-6和TGF-β1检测的临床意义
Clinical Significance of Changes on Serum IL-2, IL-6 and TGF-β1 Levels in Patients with Peptic Ulcer
厉琴 1刘畅 2樊荣 1罗红来 1王莹 1陶亮亮 1仇学明1
作者信息
- 1. 解放军第82医院消化内科,223001
- 2. 南京军区总医院消化内科,210002
- 折叠
摘要
目的:探讨消化性溃疡患者治疗前后血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和转化生长因子β1(TGF-β1)水平的变化及临床意义.方法:应用放射免疫分析对56例消化性溃疡患者进行了治疗前后血清IL-2、IL-6和TGF-β1检测,并与48例正常对照组作比较.结果:消化性溃疡患者在治疗前血清IL-2水平显著地低于正常对照组(P<0.01),而血清IL-6、TGF-β1水平又显著地高于正常对照组(P<0.01),经治疗2个月后则与正常对照组比较无显著性差异(P>0.05).结论:检测消化性溃疡患者血清IL-2、IL-6和TGF-β1水平的变化对探讨其发病机制、预防和指导用药具有重要的临床价值.
Abstract
Objective To investigate the changes in the levels of serum IL-2, IL-6 and TGF-p, of patients with peptic ulcer both before and after the treatment as well as clinical significance. Methods Adopting HIA (radioimmunoassay) to determine the levels of seium IL-2, IL-6 and TGF-β1, of 56 patients with peptic ulcer before and after the treatment as well as comparing the data with 48 healthy controls. Results The level of seium IL-2 of patients with peptic ulcer was significantly lower than that of healthy control group before treatment (P<0.01), wine the levels of serum IL-6 and TGF-β1, were obviously higher (P <0.01). However, after two months treatment, there was no significant differences between two groups (P >0.05). Conclusion Determining the changes in the levels of serum IL-2, IL-6 and TGF-β1, of patients with peptic ulcer possess significant clinical value in investigating the pathogenesis,preventing and guiding effects ofmedication.
关键词
消化性溃疡/白细胞介素-2/白细胞介素-6/转化生长因子-β1Key words
peptic ulcer/interleukin-2(IL-2)/interleukiu-6(IL-6)/transforming growth factor-β1 (TGF-β1)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据