肾素-血管紧张素-醛固酮系统在原发性高血压病中的表达
The Expression of Renin-angiotensin-aldosterone System in Primary Hypertension
王朝晖 1吴国 1李滢 1朱梅 1周晓莉 1古春艳 1阮书平1
作者信息
- 1. 湖北省十堰市郧阳医学院附属东风公司总医院核医学科,442008
- 折叠
摘要
目的:探讨血浆肾素-血管紧张素系统与原发性高血压病的关系.方法:采用放射免疫分析卧位血浆肾素活性(PRA),卧位血管紧张素Ⅱ(AngⅡ)浓度及卧立位醛固酮(ALD)浓度.使用病例-正常对照研究方案,筛选100例原发性高血压患者和我院35例血压正常者为对照组.结果:原发性高血压患者血浆卧位PRA 低于正常对照组(P<0.05),而卧、立位ALD 浓度及卧位AngⅡ浓度均高于正常对照组(P<0.05).根据高血压病1 级、2 级、3 级分组,卧位血浆PRA 呈阶梯型下降(P<0.05);而卧、立位ALD 浓度及卧位AngⅡ浓度则呈阶梯型上升(P<0.05).结论:肾素- 血管紧张素- 醛固酮系统与原发性高血压病的病因关系密切,血浆PRA 水平、AngⅡ及卧、立位ALD 浓度可能成为原发性高血压病分级和疗效的有效指标之一;降低原发性高血压患者AngⅡ及ALD 浓度是治疗高血压病的关键.
Abstract
Objective To explore the correlation between primary hypertension and renin-angiotensin-aldosterone system (RAAS) in patients. Methods The plasma levels of renin activity in supine(PRA) ,angiotensinn in supine and aldosterone in supine and standing( ALD) were measured with RlA,Using a case-normal study program, 100 patients with primary hypertension were compared to 35 normal controls. Results The plasma level of PRA in supine of the hypertensive patients was significantly lower than that of controls(P<0.05), but the plasma levels of Angll in supine and ALD in supine were obviously higher (P<0.05). With the severity of their blood pressure, the plasma level of PRA in supine decreased,but the plasma levels of Angll in supine and ALD in supine and standing increased and showed statistical difference between the groups (P<0.05) . Conclusion There was a strong association between etiology of primary hypertension and RAAS. Plasma PRA, Ang Ⅱ and ALD likely to become one of the classification of primary hypertension and efficacy of an effective indicator. The reduction of Ang Ⅱ and ALD are critical events in the treatment of hypertension.
关键词
高血压病/血浆肾素活性/血管紧张素Ⅱ/醛固酮Key words
hypertension/plasma renin activity(PRA)/angiotensin Ⅱ (Ang Ⅱ)/aldosterone( ALD)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据