慢性肾炎患者SF、血清CysC和MMP-2、MMP-9检测的临床意义
Clinical Relevance of Measurement the Changes on SF, Serum CysC and MMP-2,MMP-9 Levels Both Before and After Treatment in Patients with Chronic Nephritis
李兰亚 1张以来 2姚加平 3张春雷1
作者信息
- 1. 江苏省沭阳县中医院检验科,223600
- 2. 江苏省沭阳县中医院肾内科,223600
- 3. 江苏省灌云县人民医院检验科,222200
- 折叠
摘要
目的:探索了慢性肾炎患者治疗前后SF、血清CysC和MMP-2、MMP-9水平的变化及临床意义.方法:应用放射免疫分析和酶联法对31例慢性肾炎患者进行了治疗前后SF、血清CysC和MMP-2、MMP-9检测,并与35名正常人作比较.结果:慢性肾炎患者在治疗前SF、血清MMP-9水平非常显著地低于正常人组(P＜0.01),而CysC、MMP-2水平又非常显著地高于正常人组(P＜0.01),经中西医结合治疗3个月后与正常人组比较仍有显著性差异(P＜0.05).结论:检测慢性肾炎患者SF、血清CysC和MMP-2、MMP-9水平的变化对其病情的发展和预后的判断均有重要的临床价值.
Abstract
Objective To explore the changes of SF, serum CysC and MMP-2, MMP-9 levels both before and after treatment in patients with chronic nephritis. Methods SF (with RIA) , serum CysC and MMP-2, MMP-9 (with ELBA) levels were measured in 31 patients with chronic nephritis both before and after treatment and compared to 35 normal controls. Results Before treatment, the SF, serum MMP-9 levels were significantly lower than those in controls(P<0.01) , but serum CysC, MMP-2 levies were obviously higher than those in the controls(F < 0. 01) , after treatment of sino-westem medicinal combined therapy for 3 months, the values showed greatly correted, but still remained significantly different from those in controls(P<0.05). Conclusion Detection of SF, serum CysC and MMP-2, MMP-9 levels possess of monitoring the development and prediction in patients with chronic nephritis.
关键词
慢性肾炎/血清铁蛋白/半胱氨酸蛋白酶抑制剂-C/基质金属蛋白酶-2/基质金属蛋白酶-9Key words
chronic nephritis/serum ferritin(SF)/cysteine protease inhibitors-C(CysC)/matrix metalloprteinase-2(MMP-2)/matrix metalloproteinase-9(MMP-9)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据