慢性肾功能衰竭患者血透前后血浆leptin和血清IL-10、IL-18检测的临床意义
Clinical Significance of Determination the Changes on Plasma Leptin and Serum IL-10,IL-18 Levels Both Before and After Hemodialysis in Patients with Chronic Renal Failure
蔡伟1
作者信息
- 1. 江苏省海门市人民医院检验科,226100
- 折叠
摘要
目的:探讨慢性肾功能衰竭患者血透前后血浆leptin和血清IL-10、IL-18水平的变化及临床意义.方法:应用放射免疫分析和酶联法对32例慢性肾功能衰竭患者进行了血透前后血浆leptin和血清IL-10、IL-18水平的检测,并与35名正常健康人作比较.结果:慢性肾功能衰竭患者在血透前血浆leptin和血清IL-10、IL-18水平非常显著地高于正常人组(P＜0.01),血透2周后,呈明显下降,与正常人组比较仍有显著性差异(P＜0.05).结论:检测慢性肾功能衰竭患者血透前后血浆leptin和血清IL-10、IL-18水平的变化对了解病情、观察疗效和预后均有一定的临床价值.
Abstract
Objective To explore the clinical significance of changes on plasma leptin and serum IL-10, IL-18 levels both before and after hemodialysis in patients with chronic renal failure.Methods Plasma leptin and seium IL-10 ( with RIA) , IL-18 ( with ELISA) levels were measured both before and after hemodialysis in 32 patients with chronic renal failure as well as in 35 normal health-y controls. Results Before hemodialysis, plasma leptin and serum IL-10, IL-18 levels were significantly higher in the patients than those in contiols(P<0.01). After hemodialysis for 2 weeks the levels dropped markedlly, but still remained significantly higher than thecontrols(P<0.05). Conclusion Measuring the changes of plasma leptin and serum IL-10, IL-18 levels in patients with chronic renal failure both before and after hemodialysis, provide definite clinical value to realize of pathosis, therapeutic efficacy and prognosis.
关键词
慢性肾功能衰竭/瘦素/血液透析/白细胞介素-10/白细胞介素-18Key words
chronic renal failure/leptin/hemodialysis/interleukin-10(IL-10)/interleukin-18(IL-18)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据