糖尿病视网膜病变患者血清IL-10、IL-18和E-选择素检测的临床意义
Clinical Significance of Measurement the Changes of Serum IL-10,IL-18 and E-selectin Levels in Patients with Diabetic Retinopathy
郭灵1
作者信息
- 1. 江苏省连云港市第一人民医院东方医院眼科,222042
- 折叠
摘要
目的:探讨糖尿病视网膜病变患者血清IL-10、IL-18和E-选择素水平的变化及临床意义.方法:应用放射免疫分析和酶联法对32例无糖尿病视网膜病变患者,30例伴视网膜病变患者进行了血清IL-10、IL-18和E-选择素检测,并与35名正常健康人作比较.结果:糖尿病患者无论有无视网膜病变,患者血清IL-10、IL-18和E-选择素水平均显著地高于正常人组(P<0.01),血清IL-10水平与IL-18和E-选择素水平呈正相关(r=0.5084、06137,P<0.01).结论:血清IL-10、IL-18和E-选择素参与了糖尿病视网膜病变的发病机制,检测血清IL-10、IL-18和E-选择素水平的变化有助于糖尿病视网膜病变的诊断,有一定的临床价值.
Abstract
Objective To explore the clinical significance the measurement of changes of serum IL-10,IL-18 and E-selectin levels in patients with diabetic retinopathy. Methods Serum IL-10 (with RIA), serum IL-18, E-selectin(with ELBA) levels were measured in 32(NDR) , 30(DR) and 35 normal healthy controls. Results Serum IL-10,IL-18 and E-selectin levels in the patients with NDR and DR were significantly higher than those in controls. Serum IL-10 level was positively correlated with serum IL-18 and E-se-lectin levels(r =0.5084,06137,P<0.01). Conclusion Scrum IL-10,IL-18 and E-selectin play an important role in the pathogene-sis of diabetic retionpafliy. Detection of serum IL-10, IL-18 and E-selectin levels will be helpful for the diagnosis and therapy of diabetic retinopathy, thus provide certain value clinically.
关键词
糖尿病视网膜病变/白细胞介素-10/白细胞介素-18/E-选择素Key words
diabetic retinopathy(DR)/interleukin -10(IL-10)/interleukin -18(IL-18)/E-selectin引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据