骨转移癌患者手术前后血清IL-8、ICTP和PINP检测的临床意义
Clinical Significance of Measurement the Changes of Serum IL-8, ICTP and PINP Levels Both Before and After Operation in Patients with Bone Metastasis Malignancies
李永念 1姚加平2
作者信息
- 1. 连云港市灌云县仁济医院,222200
- 2. 连云港市灌云县人民医院,222200
- 折叠
摘要
目的:探讨了骨转移癌患者手术前后血清IL-8、ICTP和PINP水平的变化及临床意义.方法:应用放射免疫分析对31例骨转移癌患者进行了手术治疗前后血清IL-8、ICTP和PINP检测,并与35名正常健康人作比较.结果:骨转移癌患者在手术前血清IL-8、ICTP和PINP水平均非常显著地高于正常人组(P<0.01),经综合治疗6个月后与正常人组比较无显著性差异(P>0.05),且血清IL-8水平与ICTP、PINP水平呈正相关(r=0.5123、0.6012,P<0.01).结论:检测骨转移癌患者手术前后血清IL-8、ICTP和PINP水平的变化对了解病情、观察疗效和预后判断均具有一定的临床价值.
Abstract
Objective To explore the clinical relevance of measuring serum IL-8, ICTP and PINP levels both before and after op-eration in patients with bone metastasis cancer. Methods Serum IL-8, ICTP and PINP(with RIA) Levels were measured in 31 patients with bone metastasis cancer and 35 controls. Results Before operation, serum IL-8, ICTP and PINP levels were obviously higher than those in controls (P<0.01). After operation for 6 months,the serum levels were no significant difference from those of controls(P>0.05), serum IL-8 Level showed positively correlated with serum ICTP, PINP levels (r = 0.5123, 0.6012,P <0.01) Conclusion Determination of serum IL-8, ICTP and PINP Levels both before and after operation can be applied monitoring morbidity, therapeutic efficacy and prognosis, thus possess definite value clinically.
关键词
骨癌/白细胞介素-8/Ⅰ型胶原交联羧基末端肽/Ⅰ型前胶原氨基端前肽Key words
bone metastasis cancer/interleukin-8(IL-8)/cross-linked carboxyl-telopeptide of type I collagen(ICTP)/procol-lagen typel aminotenninal propeptide(PINP)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据