血浆NSE浓度与脑出血预后的相关性分析
Correlative Analysis of Plasma Neuron-specific Enolase Concentration and Prognosis of Intracerebral Hemorrhage
黄岚 1俞文华 2杜权 2董晓巧2
作者信息
- 1. 浙江省军区门诊部,310002
- 2. 杭州市第一人民医院神经外科,310006
- 折叠
摘要
目的:检测脑出血患者血浆神经元特异性烯醇化酶(NSE)浓度,评价其与脑出血预后的相关性.方法:收集急性脑出血患者和同期健康体检正常人各98例,采用ELISA测定血浆NSE浓度,统计分析其与脑出血预后的相关性.结果:脑出血患者血浆NSE浓度(14.7±4.9) μg/L显著高于体检健康者(4.2±0.7) μg/L(P<0.01).脑出血患者血浆NSE浓度与血肿量(r=0.621,P<0.01)及格拉斯哥昏迷评分(r=-0.595,P<0.01)显著相关,认定为脑出血患者3个月内死亡的独立危险因素(OR=1.231,95%CI=1.114~3.614,P<0.01),对脑出血3个月内死亡有显著预测价值(曲线下面积=0.881,95% CI=0.824~0.941,P<0.01).结论:血浆NSE与出血性脑损伤程度显著相关,可正确预测脑出血死亡.
Abstract
Objective This study aimed to determine plasma neuron-specific enolase ( NSE) concentration in patients with intracerebral hemorrhage (IGH) and to evaluate its association with disease prognosis. Methods Ninety-eight ICH patients and 98 normal healthy controls were enrolled into this study. Plasma NSE concentration was measured by E1ISA. Its association with prognosis of ICH was analyzed statistically. Results Plasma NSE concentration was obviously higher in the patients than that of healthy controls (14.7±4.9μg/Lvs. 4.2±0.7μg/L,P<0.01). Plasma NSE concentration of ICH patients was highly correlated with hematoma volume(r =0.621, P <0.01)and Glasgow coma soale(GCS) score(r= -0.595, P<0.01), identified as an independent risk factor for 3-month mortality of patients ( OR = 1.231, 95% CI = 1.114～3.614, P < 0.01) , had significant predictive value for 3-month mortality of patients (Area under curve =0.881, 95% (2 = 0.824-0.941, P<0.01). Conclusion Plasma NSE concentration is highly correlated with severity of hemorrhagic brain injury, and can accurately predict death of ICH.
关键词
神经元特异性烯醇化酶/脑出血/预后Key words
neuron-specific enolase(NSE)/intracerebral hemorrhage/prognosis引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据