摘要
目的:评估流式细胞术(flow cytometry,FCM)在多发性骨髓瘤(multiple myeloma,MM)诊断及微小残留病变(minimal residual disease,MRD)中的应用价值.方法:选取我院2009年10月~2011年10月确诊为MM的患者13例,利用流式四色荧光标记技术分析其轻链限制性表达及MRD情况.结果:FCM检测13例MM患者Kappa限制性表达6例,Lambda限制性表达7例.FCM多色方案(CD38Str/CD45+/CD19-/CD56+)可检出4例MM患者的MRD细胞.结论:FCM有助于MM的诊断,并在MM的MRD检测中具有重要意义.
Abstract
Objective To evaluate the applied value of flow cytometry(FCM)in diagnosis and minimal residual disease(MDR)of multiple myeloma(MM).Methods 13 patients with MM from October 2009 to October 2011 were selected.Their restricted light chain expression and MRD were detected by FCM.Results There were 6 kappa restricted light chain expressions and 7 lambda restricted light chain expressions.The program of CD38Str/CD45/CD19-/CD56+ will be helpful for detection of 4 MM patients's MRD cells.Conclusion FCM is of great value for diagnosis and MRD of MM.
NETL
NSTL
维普
万方数据