平均血小板体积和D-D测定在疑似深静脉血栓患者中的应用
Application of Mean Platelet Volume and D-dimer in Patients with Suspected Deep Venous Thrombosis
郎春法 1方建飞 2应群贞 3徐伟4
作者信息
- 1. 浙江省永康市第六人民医院检验科,321300
- 2. 浙江省永康市第六人民医院急诊科,321300
- 3. 浙江省永康市第一人民医院急诊科,321300
- 4. 浙江省永康市第一人民医院外科,321300
- 折叠
摘要
目的:通过测定分析急性深静脉血栓栓塞(DVT)患者的平均血小板体积(MPV)和D-二聚体(D-D)水平,旨在探讨联合使用该两项目在急性DVT中的诊断价值.方法:采集72例疑似急性DVT患者的血液,测定MPV和D-D.结果:15例经双联超声检查确诊为急性DVT患者的MPV(13.0±1.56)fl显著高于非急性DVT患者MPV( 8.76±1.07)fl(P<0.01).而且D-D结果亦显著高于非DVT患者(P<0.01).取MPV阈值为11.0fl时,MPV诊断灵敏度为71.3%,特异性为38.6%;取D-D阈值为0.5mg/L时,诊断灵敏度96.2%,特异性32.7 %;当联合应用MPV和D-D时,诊断特异性上升到71.2%.结论:测定结果提示,MPV升高与急性DVT有关,MPV升高可增加D-D对急性DVT的诊断特异性.
Abstract
Objective To analyse the diagnostic value of mean platelet volume ( MPV) and D-dimer for acute deep venous thromboembolism(DVT). Methods 72 patients with suspected lower limb DVT were recruited. Plasma levels of MPV and D-dimer were detected. Results MPV of patiems with acute DVT diagnosed by duplex ultrasonography was significantly higher than that of patients withour DVT (P<0.01). The mean MPV was 13.0±1.56fl and 8.76±1.07fl in patients with DVT and without DVT, respectively. D-dimer also presented remarkably higher in patients with DVT(P<0.01). For all the patients, a positive MPV when the cutoff value was 11.Ofl, had 71.3% sensitivity and 38.6% specificity, discretely D-dimer (with a cut-off value of 0.5mg/L) had 96.2% sensitivity and 32.7 % specificity, separately. In case of combination of MPV and D-dimer, the diagnostic specificity reached 71.2%. Conclusion The results indicated that elevated MPV was found to be associated with acute DVT and high levels of MPV might in crease the diagnostic specificity of D-dimer for exclusion of DVT.
关键词
D-二聚体/平均血小板体积/深静脉栓塞Key words
D-dimer( D-D)/mean platelet volnme( MPV)/deep venous thrombosis( DVT)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据