肺癌患者化疗前后血清Hcy、TGF-α和TGF-β1变化的临床评价
Clinical Evaluation of the Changes of Serum Hcy, TGF-α, TGF-β1 Levels After Chemotherapy in Patients with Lung Cancer
黄正军1
作者信息
- 1. 江苏省沭阳县中心医院胸外科,223600
- 折叠
摘要
目的:探讨肺癌患者化疗前后血清Hcy、TGF-α和TGF-β1水平的变化及临床意义.方法:分别采用放射免疫分析和免疫法对31例肺癌患者进行了化疗前后血清Hcy、TGF-α和TGF-β1测定,同时与35名正常健康人作比较.结果:肺癌患者在化疗前血清Hcy、TGF-α和TGF-β1水平均非常显著地高于正常人组(P<0.01),化疗后3个月与正常人组比较仍有显著性差异(P<0.05).血清Hcy水平与TGF-α、TGF-β1水平呈正相关(r=0.5132、0.6022,P<0.01).结论:检测肺癌患者血清Hcy、TGF-α和TGF-β1水平的变化与肿瘤的发生和发展密切相关.
Abstract
Objective To explore the clinical significance of the changes of serum Hcy, TGF-α and TGF-β1 levels after chemotherapy in patients with lung cancer. Methods Serum Hcy(with immune method) , serum TGF-α, TGF-β1 (with BIA)levels were measured in 31 patients with lung cancer both before and after chemotherapy. Besides, compare to 35 normal healthy controls simultaneously. Results Before chemotherapy, serum Hcy, TGF-α and TGF-β1 levels were significantly higher than thune in controls( P < 0.01). In patients with lung cancer after chemotherapy far 3 months the serum Hoy, TGF-a and TGF- β1, levels dorpped markedly but still remained distinctly higher than the controls(P <0.05). Serum Hcy,TGF-α and TGF-β1, levels were positively correlated (r = 0.5132,0.6022, P<0.01). Conclusion Serum Hcy, TGF-α and TGF-β1 levels might be closely related to the development and progression in patients with lung cancer.
关键词
肺癌/同型半胱氨酸/转化生长因子-α/转化生长因子-β1Key words
lung cancer/homocysteine (Hcy)/transforming growth factor-α(TGF-α)/transforming growth factor-β1/(TGF-β1)引用本文复制引用
出版年
2013
NETL
NSTL
万方数据