吸入糖皮质激素对支气管哮喘患儿血清NO、NOS和GM-CSF水平的影响江
Effect of Inhalation of Glucocorticoids on the Levels of Serum NO,NOS and GM-CSF in Bronchial Asthmatic Children
龚成香 1赵庆琪 2姚加平3
作者信息
- 1. 苏省连云港市灌云县仁济医院检验科,222200
- 2. 苏省连云港市灌云县仁济医院内科,222200
- 3. 江苏省连云港市灌云县人民医院,222200
- 折叠
摘要
目的:观察支气管哮喘患儿血清NO、NOS和GM-CSF水平的变化.并探讨其吸入糖皮质激素后对支气管哮喘患儿血清NO、NOS和GM-CSF水平的影响.方法:采用化学法和放射免疫分析对36例支气管哮喘患儿进行了吸入糖皮质激素前后NO、NOS和GM-CSF检测,并与35名正常健康儿作比较.结果:支气管哮喘患儿在吸入糖皮质激素前血清NO、NOS和GM-CSF水平均非常显著地高于正常儿组(P<0.01),经吸入糖皮质激素治疗3个月后与正常儿组比较仍有显著性差异(P<0.05).结论:吸入糖皮质激素是治疗支气管哮喘的重要手段,其治疗作用与下调NO、NOS和GM-CSF水平有关.
Abstract
Objective To observe the effect of inhalation of glucocorticoids on the levels of serum NO, NOS and GM-CSF in bronchial asthmatic children. Methods Serum NO, NOS (with chemistry) , serum GM-CSF (with BIA) levels were determined in 36 patients and compared with 35 normal controls. Results Before inhalation of glucocorticoids the serum NO, NOS and GM-CSF levels were significantly higher than those in the controls(P<0.01). After 3 months of inhalation glucocorticoids. the serum NO,NOS and GM-CSF levels though dropped markedly but remained apparently higher than those in the oontrols( P < 0.05). Conclusion Inhalation of glucocorticoids is an important means for bronchial asthma and the therapeutic effects closely related to the down regulation of levels of NO, NOS and GM-CSF.
关键词
支气管哮喘/一氧化氮/一氧化氮合成酶/糖皮质激素/粒-巨噬细胞集落刺激因子Key words
bronchial asthma/nitric ozide(NO)/nitrico exides synthesis (NOS)/glucocorticoids/granulocyte macrophage colony stimulating factor(GM-CSF)引用本文复制引用
出版年
2013
NETL
NSTL
万方数据