CHF患者治疗前后血浆BNP和血清SOD、IL-2检测的临床意义
Clinical Significance of the Changes on Plasma BNP and Serum SOD, IL-2 Levels Both Before and After Treatment in Patients with Chronic Heart Failure
任军生 1姚加平2
作者信息
- 1. 江苏省灌云县仁济医院,222200
- 2. 苏省灌云县人民医院,222200
- 折叠
摘要
目的:探讨了慢性心力衰竭(CHF)患者治疗前后血浆BNP和血清SOD、IL-2水平的变化及临床意义.方法:应用放射免疫分析对32例CHF患者进行了治疗前后血浆BNP和血清SOD、IL-2测定,并与35名正常健康人作比较.结果:CHF患者在治疗前血浆BNP水平非常显著地高于正常人组(P<0.01),而血清SOD、IL-2水平又非常显著地低于正常人组(P<0.01),经综合治疗2周后则与正常人组比较无显著性差异(P>0.05).血浆BNP水平与SOD、IL-2水平呈显著负相关(r=-0.5788、-0.6136,P<0.01).结论:血浆BNP和血清SOD、IL-2水平的变化参与了CHF患者的发生与发展.
Abstract
Objective To explore the clinical significance of the changes on plasma BNP and serum SOD, IL-2 levels both before and after treatment in patients with CHF. Methods Plasma BMP, serum SOD and IL-2 levels were detected with RIA in 32 patients with CHF and compared to 35 normal health; controls. Results Before treatment, the plasma BNP levels in CHF patients were significantly higher than those in controls (P<0.01) , but the serum SOD , IL-2 levels indicated markedly lower than that of controls (P <0.01) . After treatment for 2 weeks, those variables showed almost the same as in controls (P>0.05) , plasma BNP level was negatively correlatedly with serum SOD , IL-2 levels (r= -0.5788, -0.6136 , P<0.01) .Conclusion The plasma BNP and serum SOD , IL-2 levels were well correlated to the development and progression of CHF.
关键词
慢性心力衰竭/脑钠素/超氧化物岐化酶/白细胞介素-2Key words
chronic heart failure(CHF)/brain natriuretic pepn'de (BNP)/superoxide dismutase (SOD)/interleukin-2 (IL-2)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据