消化性溃疡患者外周血B细胞和T淋巴细胞亚群与胃泌素水平的相关性分析
Correlative Analysis of Peripheral Blood B, T Lymphocyte Subgroup and Serum Gastrin Levels in Patients with Peptic Ulcer
蔡伟1
作者信息
- 1. 江苏省海门市人民医院检验科,226100
- 折叠
摘要
目的:探讨消化性溃疡患者外周血B细胞和T淋巴细胞亚群与胃泌素水平的相关性.方法:应用放射免疫分析和单克隆抗体检测法对51例消化性溃疡患者进行外周血B细胞和T淋巴细胞亚群及胃泌素水平检测,并与35名正常健康人作比较.结果:消化性溃疡患者外周血B细胞数和胃泌素水平非常显著地高于正常人组(P<0.01),而外周血CD3、CD4、CD4/CD8比值又非常显著地低于正常人组(P<0.01).血清胃泌素水平与CD3、CD4水平呈显著负相关(r=-0.3927、-0.4012,P<0.01),而与B细胞呈正相关(r=0.6012,P＜0.01).结论:消化性溃疡患者存在免疫调节紊乱,其细胞免疫功能的低下与血清胃泌素水平有一定相关性.
Abstract
Objective To explore the correlation on peripheral Blood T, B lymphocyte subgroup and serum gastrin levels in patients with peptic ulcer. Methods Peripheral T lymphocyte subgroup and B cell count (with monoclonal antibody method) , serum gastrin (with RIA) levels were measured in 51 patients with peptic ulcer and 35 normal healthy controls. Resulte B cell and gastrin levels were significantly higher than those in controls((P<0.01), but CD3, CD4 and CD4/CD8 ratio were markedly lower than the controls(P<0.01). Serum Gastrin levels were negatively correlated with CD3, CD4 levels (r= -0.3927,-0.4012, ,P<0.01) ,but positively correlated with B cell(r=0.6012,P<0.01). Conclusion The existence of disturbance on cell immune regulation in patients with peptic ulcer. Between suppressed immune function and gastrin levels possess definite correlativity.
关键词
消化性溃疡/胃泌素/T淋巴细胞亚群/B细胞Key words
peptic ulcer/gastrin/T lymphocyte subset/B cell引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据