血浆UA、β2-m和hs-CRP测定对原发性高血压严重程度的评价与临床意义
The Clinical Significance and Assessment in Essential Hypertension Severity Through Determining Plasma UA,β2-m and hs-CRP Levels
陈聆1
作者信息
- 1. 江苏省苏州市永鼎医院检验科,215200
- 折叠
摘要
目的:为了研究血浆尿酸(UA)、β2-微球蛋白(β2-m)和高敏C-反应蛋白(hs-CRP)测定评价原发性高血压(EH)严重程度的临床意义.方法:应用RIA、生化法和免疫比浊分析测定了256例EH(包括76例EH3组,69例EH2组,68例EH1组和43例血压控制达标组)血浆UA、β2-m和hs- CRP水平,并与70例正常对照组进行了对比性分析.结果:256例EH患者血浆UA水平为(373.4±117.6)μmol/L,较之70例正常对照组明显增高(P<0.01),从43例血压控制达标组至76例EH3组随EH患者的严重程度逐渐增高,较之70例正常对照组从无明显差异至明显增高(P>0.05~P<0.01).256例EH患者血浆β2-m和hs-CRP水平分别为(9.48±5.03)mg/L和(4.38±1.31)mg/L,较之正常对照组明显增高(P<0.001和P<0.01).并随EH患者的严重程度而不断增高(P>0.05~P<0.001).结论:EH患者血浆UA、β2-m和hs-CRP水平的测定是衡量其病情严重程度的良好指标,而且血浆hs-CRP具有预示心血管事件发生的一定临床价值.
Abstract
Objective In order to study the clinical significance and evaluation of essential hypertension (EH) severity through determining plasma uric acid(UA) , β2-microglobulin(β2-m)and high-sensitire C-reaction protein(hs-CRP) levels. Methods RIA, biochemistry method and high-sensitive immunoturbidunetry used to measure plasma UA, β2-m and hs-CRP levels in 256 patients with EH(EH,including 76 cases EH3 section,69 cases EH2 section,68 cases EH1 section and 43 cases blood presure normal section) and 70 controls,followed all of determinations with a comparative analysis. Results The plasma UA levels in 256 patients with EH were 373.4 ±117.6μmol/L and were significantly higher than those in 70 controls(P <0.01) ,there were increased gradually with EH severity from 43 cases blood pressure normal section to 76 cases EH3 section, and showed no significant difference to significantly higher than the controls(P >0.05～P<0.01). The plasma β2-m and hs-CRP levels in 256 patients with EH were 9.48 ±5.03mg/L and 4.38 ±1.31mg/L and manifested obviously higher than that of controls(P<0.001 and P<0.01), and continuously increased with EH severity(P>0.05～P<0.001) .Conclusion The severity of the patients with EH determining of UA, β2-m, hs-CRP levels were a good and valuable index, respectively. Also, plasma GRP could be utilize to predict cardiovascular events, and thus provides definite clinical value.
关键词
原发性高血压(EH)/尿酸(UA)/β2-微球蛋白(β2-m)/超敏C-反应蛋白(hs-CRP)/严重程度/心血管事件Key words
essential hypertension (EH)/uric acid(UA)/β2-microglohulin(β2-m)/high-sensitive C-reactive protein ( hs-CRF)/severity/cardiovascular events引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据