血浆IL-18浓度与脑梗死预后的相关性分析
Correlative Analysis of Plasma Interleukin-18 Concentration and the Prognosis on Cerebral Infarction
黄日忠1
作者信息
摘要
目的:揭示脑梗死患者血浆IL-18浓度与预后的相关性.方法:检测86例体检健康者和86例急性脑梗死(ACI)患者血浆IL-18浓度,对其进行统计学分析.结果:ACI患者血浆IL-18浓度(465.3±187.6)pg/ml较体检健康者(124.8±41.6)pg/ml显著升高(P<0.01),与入院时美国国立卫生院神经功能缺损评分显著正相关(r=0.649,P<0.01),是ACI 1年内预后不良(OR=1.246,95%CI=1.112~1.983,P<0.01)和死亡(OR=1.401,95%CI=1.139～2.236,P<0.01)的独立危险因素,可明显预测ACI 1年内不良后果(曲线下面积=0.865,95%CI=0.802~0.923,P<0.01)和死亡(曲线下面积=0.873,95%CI=0.814~0.932,P<0.01).结论:ACI后血浆IL-18显著升高,临床检测这个指标有助于早期判断ACI的预后.
Abstract
Objective This study aimed to investigate the correlativity between plasma interleukin-18 level and prediction of cerebral inarction. Methods Plasma interleukin-18(IL-18) concentration was determined in 86 healthy controls and 86 patients with a-cute cerebral infarction. Statistical analysis was made. Results The plasma IL-18 level(465.3 ± 187.6) pg/ml in the patients was significantly higher than that (124.8 ±41.6) pg/ml in the healthy controls (P<0.01) and highly associated with National Institutes of health stroke scale score (r =0.649, P<0.01). Indicated IL-18 was an independent risk factor for 1-year poor outcome (OR = 1.246,95%CI = 1.112-1.983, P<0.01) and mortality(OR= 1.401, 95%CI =1.139-2.236, P<0.01) Besides prediction of l-year poor outcome (area under curve =0.865, 95%CI=0.802 ～0.923, P<0.01)and mortality (area under curve =0.873, 95% CI =0.814～0.932, P<0.01)obviously. Conclusion Plasma IL-18 level enhanced dramatically after cerebral infarction. Its clinical determination can be beneficial to early evaluate the prognosis of cerebral infarction.
关键词
白介素-18/脑梗死/预后Key words
interleukin-18/cerebral infarction(CI)/prognosis引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据