内脂素与妊娠糖尿病及产后糖尿病关系的临床分析
Clinical Analysis of the Relationship with the Effect of Serum Vaspin on Gestational Diabetes and Postpartum Diabetes
吴金友 1薛城 1林海洋 1程怡 1毛小洁1
作者信息
- 1. 温岭市第一人民医院内分泌科,317500
- 折叠
摘要
目的:探讨内脂素与妊娠糖尿病(GDM)及产后糖尿病的关系.方法:以GDM患者为对象,将糖耐量正常的妊娠者作对照.首先比较不同妊娠周期及产后血糖、胰岛素、稳态模型胰岛素抵抗指数(HOMA-IR)、内脂素及体重指数(BMI)的差别;然后,采用单因素相关分析法探讨内脂素与上述指标的相关性;最后,比较产后糖尿病组和非糖尿病组妊娠期及产后半年内脂素水平的差异.结果:①内脂素和HOMA-IR在两组均2期妊娠时最高,产后最低,但试验组高于同时点对照组,差异有统计学意义(P<0.01);②试验组妊娠期内脂素与胰岛素(r=0.356,P＜0.05)和HOMA-IR(r=0.386,P＜0.05)正相关;③产后糖尿病组和非糖尿病组妊娠期及产后半年内脂素水平比较,差异无统计学意义(P>0.05).结论:内脂素与GDM相关,但不能预测产后糖尿病.
Abstract
Objective To explore the relationship with the effect of serum vaspin on gestational diabetes mellitus( GDM) and postpartum diabetes mellitus( PDM). Methods 73 patients suffered GDM were divided into the observed group, and 73 patients with normal glucose tolerance were served as control group. The differences of the blood glucose, insulin, homeostasis model insulin resistance index ( HOMA-IR ) , serum vaspin and body mass index ( BMI) were compared between the two groups. And single factor correlative analysis was used to explore the above indicators. Finally, the difference of serum vaspin between the patients with or without PDM was compared. Results ①The serum vaspin and HOMA-IR in both observe group and control group decreased significantly from the second trimester to postpartum, but the level in the observed group were significantly lower than that in the control group (P < 0.05). ②At the pregnancy, the vaspin was positively correlated to insulin and HOMA-IR in the observed group, and not in the control group and poetpartum. ③There's no significant difference of serum visfatin between the patients with or without postpartum diabetics (P >0.05). Conclusions Vaspin is associated with GDM, but could not predict PDM.
关键词
内脂素/妊娠糖尿病/妊娠期/产后Key words
vaspin/gestational diabetes mellitus/pregnancy/postpartum引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据