常用血清学指标对肝纤维化程度的预测价值
Predictable Value of the Common Serum Indexes for Predicting the Severity of Liver Fibrosis
朱远航 1朱冬林 1陈江玲1
作者信息
- 1. 中山大学附属第三医院检验科,510630
- 折叠
摘要
目的:观察常用血清学指标与慢性肝炎肝纤维化程度的关系,以期找到可预测明显肝纤维化的血清学指标.方法:回顾性调查160例慢性肝炎患者资料,以病理学肝纤维化分期将患者分为S0、S1、S2、S3、S4共五组,同时检测、记录患者常规生化指标并用放射免疫分析肝纤维化四项标志物,然后分析各指标与肝纤维化分期的相关性.以病理学肝纤维化分期S2作为分界将患者分成轻度肝纤维化(S0-S1)和明显肝纤维化(S2-S4)两组,对各指标进行单变量分析,并在此基础上运用多因素logistic回归分析筛选出与肝纤维化分期相关的独立预测因子.结果:选取的各项血清学指标与肝纤维化分期有较好的相关性.单因素分析显示,胆碱酯酶、血清前白蛋白两项指标诊断明显肝纤维化ROC曲线下面积(AUC)>0.7.经多因素logistic回归分析确定胆碱酯酶显著影响肝纤维化分期,可用于预测明显肝纤维化,预测准确率达72.5%.结论:在慢性肝炎常用肝功能指标中,多项指标与肝纤维化程度有相关性.胆碱酯酶显著影响肝纤维化分期,可用于预测明显肝纤维化.
Abstract
Objective To observe the relationship between the common serum biochemical indexes and the degree of liver fibrosis, and expected to find indexes for predicting the obvious liver fibrosis. Methods One hundred and sixty cases were divided into five groups (S0, S1, S2, S3 and S4) according to the results of pathological biopsy. The levels of the common serum biochemical indexes were detected and the correlation between indexes and liver fibrosis degree were analyzed. After the fibrotic levels were classified in two stratifications, which were non-significant fibrosis ( S0-S1) and significant fibrosis ( S2 -S4) , independent risk factors for predicting liver fibrosis were screened from the common serum biochemical indexes. Results It was observed that the most serum biochemical indexes were significantly correlated with the clinical stages of liver fibrosis. Single factor analysis showed that the AUC > 0.7 for cho-linesterase and serum prealbumin, and cholinesterase was identified by multivariate logistic regression analysis as independent factors of fibrosis. Conclusion More serum biochemical indexes were significantly correlated with the clinical stages of liver fibrosis and cholinesterase can be used to predicting the obvious liver fibrosis.
关键词
肝炎慢性/肝纤维化/病理活检/相关性/预测Key words
chronic hepatitis/liver fibrosis/pathological biopsy/correlation/predicting引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据