食管癌患者手术前后血清E- cad、SICAM-1和IL-8检测的临床意义
Clinical Significance of Measurement the Changes on Serum E-cad, SICAM-l and IL-8 Levels in Postoperative Patients with Esophageal CancerHuang
黄正军1
作者信息
- 1. 江苏省沭阳县中心医院胸外科,223600
- 折叠
摘要
目的:探讨了食管癌患者手术前后血清E-cad、SICAM-1和IL-8水平的变化及临床意义.方法:应用放射免疫分析和酶联法对33例食管癌患者进行了手术前后血清E-cad、SICAM-1和IL-8检测,并与35名正常健康人作比较.结果:食管癌患者在手术前血清E-cad、SICAM-1和IL-8水平均非常显著地高于正常人组(P<0.01),手术治疗6个月后则与正常人组比较无显著性差异(P>0.05).血清E-cad水平与SICAM-1、IL-8水平呈正相关(r=0.6188、0.5012,P<0.01).结论:检测食管癌患者手术前后E-cad、SICAM-1和IL-8水平的变化具有真实的价值.
Abstract
Objective To explore the clinical significance of determining the changes on seium E-cad, SICAM-1 and IL-8 levels after operation in patients with esophageal cancer . Methods Serum IL-8 (with RIA) and serum E- cad, ICAM-1(with ELSA) levels were determined in 33 patients with esophageal cancer both before and after operation as well as in 35 normal healthy controls. Results Before operation the serum E- cad, ICAM-1 and IL-8 levels in the patients were significantly higher than those in the controls(P < 0.01). After operation far6 months serum E- cad, ICAM-1 and IL-8 levels showed no mare difference from the controls(P>0.05). Serum E- cad level was positively correlated with ICAM-1, IL-8 levels (r =0.6188,0.5012,P<0.01). Conclusion Changes of serum E- cad ICAM-land IL-8 levelsmight be of substantial prognostic value in patients with esophageal cancer.
关键词
食管癌/上皮钙粘蛋白/可溶性细胞粘附分子-1/白细胞介素-8Key words
esophageal cancer/E-cadherin( E-cad)/soluble intercellular adhesion molecnle-1(SICAM-1)/interleukin-8 (IL-8)引用本文复制引用
出版年
2013
NETL
NSTL
万方数据