首页|肺癌患者化疗前后血清Hcy、IGF-Ⅱ和EGF检测的临床意义

肺癌患者化疗前后血清Hcy、IGF-Ⅱ和EGF检测的临床意义

Clinical Significance of Measurement the Changes of Serum Hcy, IGF-Ⅱ and EGF Levels Both Before and After Chemotherapy in Patients with Lung Cancer

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目的:探讨肺癌患者化疗前后血清Hcy、IGF-Ⅱ和EGF水平的变化及临床意义.方法:应用化学发光法和放射免疫分析对32例肺癌患者进行了化疗前后血清Hcy、IGF-Ⅱ和EGF检测,并与35例正常健康人作比较.结果:肺癌患者在化疗前血清Hcy、IGF-Ⅱ和EGF水平非常显著地高于正常人组(P<0.01),经化疗6个月后与正常人组比较仍有差异(P<0.05),血清Hcy水平与IGF-Ⅱ、EGF水平呈正相关(r=0.4984、0.5126,P<0.01).结论:肺癌患者的发生、发展与血清Hcy、IGF-Ⅱ和EGF水平的变化密切相关.
Objective To explore the clinical significance of changes of serum Hcy, IGF- Ⅱ and EGF levels both before and after chemotherapy in patients with lung cancer. Methods Serum Hcy (with ECLIA) , serum IGF- Ⅱ, EGF (with RIA) levels were determined both before and after chemotherapy in 32 patients with lung cancer as well as in 35 normal healthy controls. Result Before chemotherapy, serum Hcy, IGF-Ⅱ and EGF levels were significantly higher in patients than those in controls(P<0.05) , six months after chemotherapy, serum Hcy, IGF- Ⅱ and EGF levels dropped markedly, but remained obviously higher than those in conrrols(P< 0.05), serum Hcy level was positively correlated with serum IGF-Ⅱ, EGF levels(r=0.4984,0.5126, P<0.01). Conclusion The development and progress in patients with lung cancer indicated closely related to the serum Hcy, IGF-Ⅱ and EGF levels.

lung cancerhomocysteine( Hcy)insulin-like growth factor-Ⅱ (IGF-Ⅱ )epithelial growth factor(EGF)

龚成香、王明生、姚加平

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连云港市灌云仁济医院检验科,222200

连云港市灌云仁济医院内科,222200

连云港市灌云县人民医院,222200

肺癌 同型半胱氨酸 胰岛素样生长因子-Ⅱ 上皮细胞生长因子

2013

10.3969/j.issn.1008-9810.2013.04.008

放射免疫学杂志
同济大学

放射免疫学杂志

CSTPCD
影响因子：0.508
ISSN：1008-9810
年,卷(期)：2013.26(4)
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