原发性高血压患者治疗前后血浆ET-1和血清NO、CGRP检测的临床意义
Clinical Significance of Measurement the Changes of Plasma ET-1 and Serum NO, CGRP Levels Both Before and After Treatment in Patients with Essential Hypertension
任军生 1姚加平2
作者信息
- 1. 江苏省连云港灌云仁济医院,222200
- 2. 连云港市灌云仁济医院,222200
- 折叠
摘要
目的:探讨原发性高血压患者治疗前后血浆ET-1和血清NO、CGRP水平的变化及临床意义.方法:应用放射免疫分析和化学法对33例原发性高血压患者进行了治疗前后血浆ET-1和血清NO、CGRP测定,并与35名正常健康人作比较.结果:原发性高血压患者在治疗前血浆ET-1水平非常显著地高于正常人组(P<0.01),而血清NO、CGRP水平又非常显著地低于正常人组(P<0.01),经治疗2个月后则与正常人组比较无显著性差异(P>0.05).血浆ET-1水平与NO、CGRP水平呈显著负相关(r=-0.5728、-0.4822,P<0.01).结论:检测原发性高血压患者血浆ET-1和血清NO、CGRP水平的变化对探讨其发病机制提供了有价值的实验室依据.
Abstract
Objective To explore the clinical significance of measurement the changes of plasma ET-1 and serum NO , CGRP levels both before and after treatment in patients with essential hypertension . Methods Plasma ET-1 and serum CGRP (with RIA) , serum NO (with chemistry )levels measured in 33 patients with essential hypertension and compared to 35 normal healthy indivills as control. Results Before treatment , plasma ET-1 level was significantly higher than that in controls (P <0.01). But serum NO, CGRP levels were showed evidently lower than the controls (P<0.01) . Plasma ET-1 level indicated negatively correlated with serum NO and CGRP levels (r =-0.5728,-0.4822 , P<0.01) .Conclusion Detection of plasma ET-1 and serum NO , CGRP levels after treatment provides a valuable laboratory basis for the exploration of the pathogenesis in essential hypertension.
关键词
原发性高血压/内皮素-1/一氧化氮/降钙素基因相关肽Key words
essential hypertension/endothelial-1 (ET-1)/nitric oxide (NO)/calcitonin gene-related peptide (CGRP)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据