侵袭性牙周炎患者血清IL-2、IL-10和β-防御素-2检测的临床意义
Clinical Significance of Measurement the Changes of Serum IL-2, IL-10 and Beta-Defensin-2 Levels in Patients with Aggressive Periodontitis.
王统伍1
作者信息
- 1. 江苏省连云港市第一人民医院苍梧分院,222006
- 折叠
摘要
目的:探讨侵袭性牙周炎患者治疗前后血清IL-2、IL-10和β-防御素-2水平的变化及临床意义.方法:应用放射免疫分析和酶联法对40例侵袭性牙周炎患者进行了治疗前后血清IL-2、IL-10和β-防御素-2检测,并与35名正常健康人作比较.结果:侵袭性牙周炎患者在治疗前IL-2和β-防御素-2的水平均显著地低于正常人组(P<0.01),而IL-10水平又显著地高于正常人组(P<0.01).经治疗3个月后与正常人组比较仍有显著性差异(P<0.05).结论:侵袭性牙周炎患者血清IL-2和β-防御素-2水平的降低与IL-10水平的升高可能是侵袭性牙周炎的独立危险因素.
Abstract
Objective To explore the clinical significance of changes on serum IL-2, IL-10 and beta-defensin-2 levels both before and after treatment in patients with aggressive periodontitis. Msthods Serum IL-2, IL-10 (with RIA) and beta-defensin-2 (with ELISA) levels wece determined in 40 patients with aggressive periodontitis and 35 normal healthy controls. RosultS Before treatment, serum IL-2 and beta-defensin-2 levels were significantly lower than those in controls (P<0.01). But serum IL-10 leveb were markedly higher than that of controls (P <0.01). After treatment for 3 months, the levels changed notably by toward normal, but remained significant difference from the controls (P<0.05). Conclusion Decreased serum IL-2, beta-defensin-2 and increased IL-10 was found after aggressive periodontitis may be uniquely of risk factor.
关键词
侵袭性牙周炎/白细胞介素-2/白细胞介素-10/β-防御素-2Key words
aggressive periodontitis/interleukin-2(IL-2)/interleukin-10(IL-10)/beta-defensin-2引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据