ACI患者血清Hsp70、Copeptin和S100B水平与认知功能障碍的相关性分析
Correlative Analysis of Relationship Between the Serum Hsp70, Copeptin and S100B Levels with Cognitive Dysfunction in Patients with Acute Cerebral Infartion
薛建中1
作者信息
- 1. 扬州大学第五临床医学院常熟市二院神经内科,215500
- 折叠
摘要
目的:探讨急性脑梗死(acute cerebral infarction,ACI)患者血清三项指标水平的变化与认知功能障碍的关系.方法:本文设置了ACI病(30例)和高风险病(30例)及正常对照组进行比较.血清热休克蛋白70(heat shock protein70,Hsp70) 及和肽素(copeptin) 采用ELISA;S100B蛋白(S100B protein) 采用电化学发光免疫分析法.结果:高风险病组和ACI组患者六项常规临床检查指标均显著高于正常对照组(P均<0.01),而两疾病组之间均无统计学差异(P均>0.05).高风险病组三项血清指标水平与正常对照组比较均无统计学差异(P均>0.05),ACI后24h组则三项血清指标水平显著高于正常对照组和高风险病组(P<0.01,P<0.05).梗死后3d测定的三项血清指标水平梗死后认知功能障碍组(B组)显著高于梗死后非认知功能障碍组(A组).本文统计梗死后认知功能障碍发生率为39.2%,与B组的三项血清指标水平相关性分析显示,呈显著正相关(r=0.520、0.615、0.701,P＜0.05、P＜ 0.05、P<0.05).结论:三项血清标志物以其不同方式参与了ACI的病理机制;其测定对于了解与认知功能障碍的关系有一定临床价值.
Abstract
Objective To explore the relationship between the changes on three serum indicators with cognitive dysfunction in patients with acute cerebral infarction. Methods The article established ACI groups(n =30) , high risk disease group(n =30) and healthy individuals served as normal control group (n =34). The serum levels of Hsp70, copeptin (with ELISA) and S100B (with ECLIA) were determined and made a comparison between the three groups. Results Six routine clinical indexes of AGI group and high risk disease group were higher than those in normal control group(all P < 0.01) , however, the above indexes levels proved no significant difference between the two groups of patients( all P >0.05). From table 2, all three serum indicators levels expressed no significant differences in high risk disease group compared with the normal control group (all P>0.05) , and the serum levels of cerebral infarction group were significantly higher than those in the control group ( all P<0.01). Besides, the levels showed markedly higher in cerebral infarction group than those in the high risk disease group(.P <0.01,P <0.05). The serum levels of three indexes manifested significantly higher by 3d after cerebral infarction in B group than those in A group.The incidence of cognitive of cognitive dysfunction was signifi- cantly correlated with the levels of serum three indicatore(r=0.520,0.615,0.701 ,P<0.05,P<0.05,P<0.05). Conclusion Tie changes of serum levels of 3 indexes were objectively reflect it could take part in pathogenesis of ACI in various ways, the determination provides definite clinical values for realize the relationship between these serum items levels among cognitive dysfunction.
关键词
急性脑梗死/热休克蛋白70/和肽素/S100B蛋白/认知功能障碍Key words
acute cerebral infarction/heat shock protein70/copeptin/S100B protein/cognitive dysfunction引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据