CHD患者血清PAPP-A、ICAM-1和hs-CRP检测的临床价值
The Clinical Values of Serum PAPP-A，ICAM-1 and hs-CRP Levels in Patients with Coronary Heart Diseases
任军生 1姚加平2
作者信息
- 1. 江苏省连云港灌云仁济医院,222200
- 2. 江苏省灌云县人民医院,222200
- 折叠
摘要
目的:探讨冠心病(CHD)患者治疗前后血清妊娠相关蛋白A(PAPP-A)、血管细胞间黏附分子-1(ICAM-1)和超敏C-反应蛋白(hs-CRP)水平的临床应用价值.方法:采用化学放光法、酶联法和免疫比浊法对66例CHD患者进行了治疗前后血清PAPP-A、ICAM-1和hs-CRP检测,其中稳定型心绞痛(SAP)30例,不稳定型心绞痛(UAP)23例,急性心肌梗死(AMI)13例,并以35名正常健康人作比较.结果:CHD患者在治疗前血清PAPP-A、ICAM-1和hs-CRP水平均非常显著地高于正常人组(P<0.01),经中西医结合治疗3个月后则与正常人组比较无显著性差异(P>0.05).结论:血清PAPP-A、ICAM-1和hs-CRP水平的变化与CHD的发生、发展密切相关.
Abstract
Objective To explore the clinical values of serum PAPP-A,ICAM-1 and hs-CRP levels both before and after treatment in patients with coronary heart diseases.Methods Serum PAPP-A(with CLIA),serum ICAM-1 (with ELSA) and serum hs-CRP (with immunoturbidimetry) levels in 66 patients with coronary heart diseases both before and after treatment(30 SAP,23 UAP,13 AMI) and 35 normal healthy controls . Results Before treatment,serum PAPP-A,ICAM-1 and hs-CRP levels showed significantly higher than those in controls (P<0.01) , after treatment for 3 months,those variables expressed about the same as in controls (P> 0.05).Conclusion The serum PAPP-A,ICAM-1 and hs-CRP levels manifested well correlated to the development and progress of coronary heart diseases.
关键词
冠心病/妊娠相关蛋白A/血管细胞间粘附分子-1/超敏C-反应蛋白/稳定型心绞痛/不稳定型心绞痛/急性心肌梗死Key words
coronary heart diseases( CHD)/pregnancy-associated plasma protein-a( PAPP-A)/adhesion molecule-1/high sensitivity C-reactive protein (hs-CRP)/stable angina pectoris (SAP)/unstable angina pectoris (UAP)/acute myocar-dial infarction (AMI)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据