Objective To explore the clinical significance of changes on serum cortisol and adrenocorticotropic hormone(ACTH) in impaired glucose regulation and type 2 diabetes mellitus patients. Methods Subjects were divided into three groups;IGR group (IGT and/or IFG) , DM2 group and control group, compare with cortisol and ACTH concentration at 8:00,24:00 in twice IGR group subdivision IGT group and IFG group, with DM2 group compare to Cortisol and ACTH levels at 8:00, 24:00 in twice concentration. Results ①The serum levels of 8:00,24:00 in twice cortisol and ACTH in IGR and DM2 diabetics presented all remarkably higher than those in control group( P< 0.01 orP< 0.05) ;② The serum levels of 8:00 cortisol and ACTH in DM2 group showed all significantly lower than the of IGT and IFG group(P< 0.01 or P< 0.05 );③ The serum level of Cortisol manifested all positively correlated with ACTH in impaired glucose regulation and type 2 diabetes pan'ents(r = 0.4002,0.4231, P<0.05). Conclusion Cortisol and ACTH secretion rise in DM2 and IGR group, which suggests have regulated distubance of the HPA axis,HPA function exhaustion might be associated with the progression of disease.
NETL
NSTL
维普
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