前列腺癌患者的血清IL-6、性激素和PSA水平的临床评价
The Clinical Assessment of Serum IL-6,Sex Hormone and PSA Levels in Patients with Prostate Cancer
朱同华1
作者信息
- 1. 江苏省苏州市吴江区第一人民医院检验科,215200
- 折叠
摘要
目的:探讨前列腺癌(prostate cancer,PCa)患者血清白介素-6(IL-6)、性激素和前列腺特异性抗原(prostate specific antigen,PSA)的水平及其临床评价.方法:采用化学发光免疫分析法测定了178例前列腺疾病[其中68例PCa,43例前列腺增生(BPH),31例BPH+急性尿潴留(AUR)和36例急性前列腺炎(AP)]患者和60例正常对照组血清IL-6、T、FSH和 LH以及PSA的水平,并同时进行比较性分析.结果:在178例前列腺疾病中,68例PCa患者血清IL-6水平较43例BPH、31例BPH+AUR、36例AP患者和60例正常对照组均明显增高(P<0.01、<0.05、<0.05和<0.01).在性激素分析中,68例PCa患者血清T水平较60例正常对照组明显降低(P<0.01),其他各组均正常(P均 >0.05);68例PCa患者血清FSH水平较60例正常对照组明显增高(P<0.01),43例BPH和36例AP患者均正常(P均>0.05),而31例BPH+AUR患者稍增高(P<0.05);68例PCa患者血清LH较60例正常对照组明显增高(P<0.05),而31例AP患者明显降低,有待进一步探讨.在PSA测定中,68例PCa患者血清PSA较其他前列腺疾病组和60例正常对照组非常明显增高(P均<0.01),在68例PCa患者中,37例骨转移患者的血清IL-6和PSA水平较31例未转移患者明显增高(P分别为<0.01和<0.05),性激素之间无明显差异(P均>0.05).结论:PCa患者血清IL-6、FSH、LH和PSA水平明显增高和血清T明显降低是诊断和鉴别前列腺良恶性疾病的有价值的临床指标,而PCa患者骨转移的典型特点是血清IL-6和PSA水平的增高,但与血清性激素水平无关.
Abstract
Objective To explore the clinical assessment of serum IL -6, sex hormone and PSA levels in patients with prostate cancer (PCa). Methods The serum IL-6,sex hormone(T,FSH and LH) and PSA levels in 178 patients with prostate diseases (including 68 cases PCa, 43 cases BPH, 3leases BPH + AUR and 36 cases AP ) and 60 controls were determined by chemiluminescent immunoassay and comparative analysis was made simueltaneously. Results In 178cases prostate diseases. The serum IL-6 level in 68 patients with PCa showed apparently higher than that in 43 cases BPH, 31 cases BPH + AUR, 36 cases AP and 60 controls (P<0.01, <0.01. <0.05 and <0.01 respectively). In sex hormone, the serum T level in 68 patients with PCa presented significantly lower than that of controls (P<0.01) ,other groups were normal (P all>0.05). The serum FSH level in 68 patients with PCa proved re- markably higher than that in 60 controls (P<0.01),43 cases BHP and 36 cases AP expressed normal (P all >0.05) ,but 31 cases showed minor increased (P <0.05). The serum LH level in 68 patients with PCa indicated significantly higher than that in 60 controls (P <0.05) also, but 31 cases AP was significantly decreased and remained for further study. In PSA determination, the serum PSA level in 68 patients with PCa proved obviously higher than that in other prostate diseases and 60 controls (P all <0.01). In 68 cases PCa, the serum IL-6 and PSA in 37 cases PCa with having bone metastasis showed notably higher than 31 cases without bone metastasis (P<0.05 and <0.01 respectively) , but the serum hormone presented no significantly different (P all >0.05) , Conclusion The serum IL-6,FSH,LH and PSA levels much increased but T much decreased were great clinical value for diagnosis and identification of PCa and benign prostate diseases, the serum IL-6 and PSA levels increased in PCa with having bone metastasis were typical feature, but the serum sex hormone levels indicated no conelativity.
关键词
前列腺癌(PCa)/白介素-6(IL-6)/性激素/前列腺特异性抗原(PSA)Key words
prostate cancer(PCa)/interleukin 6(IL-6)/sex hormone/prostate specific antigen(PSA)引用本文复制引用
出版年
2013
NETL
NSTL
万方数据