急性髓系白血病177例免疫分型特点及预后分析
Relationship Between Immunological Classification and Prognostic Analysis in 177 Cases of Acute Myeloid Leukemia
周国忠 1傅佳萍 2俞淑丽1
作者信息
- 1. 浙江省绍兴市人民医院临床检验中心,312000
- 2. 浙江省绍兴市人民医院血液科,312000
- 折叠
摘要
目的:探讨急性髓系白血病(AML)患者免疫分型的特点及临床意义.方法:采用CD45/SSC双参数散点图设门方法对177例急性髓系白血病患者进行三或四色流式细胞术免疫分型分析.结果:177例AML显示,CD33,CD38,CD117,CD13及HLA-DR高度表达,阳性率分别为92.66%,81.36%,75.14%,68.93%和67.80%.40.7%的AML患者伴有淋系抗原表达,最常见的是CD7(22.6%),其次是CD19(7.91%).结论:多色流式细胞仪术免疫分型对AML的诊断及预后具有重要意义.
Abstract
Objective To explore the characteristics of immunophenotyping in acute myeloid leukemia( AML). Methods Im-munophenotyping was performed by three or four color flow-cytometry using CD45/SSC gating. Results In 177 patients with AML,the myeloid antigen of CD33.CD38, CD117, CD13 and HLA-DR showed highly expressed. The positive rate was 92. 66% ,81. 36% , 75.14% ,68.93% and 67.8%. About 40.7% of lymphoid-associated antigen expression of all the AML patients. The lymphoid-associ-ated antigens of CD7 and CD19 expression in patients with AML was 22.6% and 7.91% , individually. Conclusion Multi-color flow-cytometry on immunological classification of AML provides important significance for diagnosis and prognosis of AML.
关键词
急性髓系白血病/免疫表型分析/流式细胞术Key words
acute myeloid leukemia(AML)/immunophenotyping/flow cytometry引用本文复制引用
基金项目
绍兴市科技资助项目(2012B70051)
出版年
2013
NETL
NSTL
维普
万方数据