动态监测降钙素原在糖尿病足合并感染中的临床意义
Clinical Significance of Dynamic Monitoring of Serum Procalcitonin Levels in Patients with Diabetic Foot Infections
赵理平1
作者信息
- 1. 广东省珠海市妇幼保健院检验科,519000
- 折叠
摘要
目的:探讨降钙素原(PCT)在糖尿病足合并感染中监测的临床意义.方法:对50例糖尿病足合并感染患者中34例PCT阳性患者,进行抗生素使用后3d、7d、14d的PCT水平连续监测和数据统计分析.结果:PCT阳性患者首次含量为(12.45±2.91)ng/ml,显著高于PCT阴性病例和健康体检正常人组(P<0.01);在抗生素使用后的3d、7d、14d,PCT值明显下降,阳性率逐次降分别为48.98%、28.57%、10.20%,与入院当天68%比较,差异均有统计学意义(P<0.05、P<0.01、P<0.01).结论:血清PCT水平与患者感染的严重程度、抗生素的及时应用及疾病转归密切相关,动态监测PCT在糖尿病足合并感染病程中的变化,对评估感染病情、指导抗生素使用、判断转归预后具有重要的临床意义.
Abstract
Objective To explore the clinical significance of dynamic monitoring of serum procalcionin (PCT) level in patients with diabetic foot infections. Methods Serum PCT level was horizontaly continuously detected and their statistical data was analyzed after 3d, 7d, 14d used antibiotic in 34 PCT positive patients of 50 patients with diabetic foot infections . Results The first content of PCT positive patients showed 12.45 2.91ng/ml, significantly higher than that of PCT negative cases and healthy controls(P <0.01). In the use of antibiotics after 3d, 7d, 14d, PCT value decreased, the positive rate of successive descending for 48.98% ,28.57% , 10.20% respectively. And compared to 68% positive rate on the day of hospitalization, the differences proved statistically significant ( P < 0.05, P < 0.01). Conclusion The serum PCT level in patients with the severity of the infection, antibiotics timely application and prognosis of the disease are closely related. The changes in the course of diabetic foot infections, by dynamic monitoring of PCT provides important clinical significance on the assessment of infection disease, guide antibiotic use and judging prognosis.
关键词
降钙素原/糖尿病足合并感染/动态监测/疗效判断Key words
procalcitonin(PCT)/diabetic foot infections/dynamic monitoring determination/curative effect evaluation引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据