NT-proBNP与ST段抬高型急性心肌梗死(STEMI)首次PCI术后不良疗效相关性分析
Correlative Analysis of NT-proBNP and STEMI on Adverse Short-term Outcomes in STEMI Patients Underwent Primary PCI
车璐 1曹艳菲 1张丽娜1
作者信息
摘要
目的:应用血清N-端脑钠肽前体(N-terminal pro-B type natriuretic peptide,NT-proBNP)水平判断ST段抬高型急性心肌梗死(ST-elevated myocardial infarction,STEMI)患者经首次PCI术后是否出现不良疗效.方法:入组STEMI患者184例,年龄(61.5±12.6)岁,男性占71.5%,入院12h内行经皮腔内冠状动脉成形术(percutaneous coronary intervention,PCI)术.电化学免疫发光法(electrochemiluminescenceassay,ECLIA)检测血清NT-proBNP水平,根据NT-proBNP水平将入组患者分组对照观察.结果:血清NT-proBNP水平>990pg/ml(n=76例,男性55.8%)组与血清NT-proBNP水平≤990pg/ml(n=108例,男性75.2%)组比较,低左室射血分数(left ventricle ejection fraction,LVEF)(47.7±12.2% vs 53.2±10.8%,P<0.001),需要监护天数(3.8±3.6 vs 2.3±2.7d,P<0.001),院内死亡率(7.2% vs 1.3%,P<0.001).结论:实验提示,血清NT-proBNP水平与STEMI患者经初次PCI术后短期内死亡率相关.
Abstract
Objective To evaluate the early outcomes of patients with STEMI accoiding to the level of senim NT-proBNP to predict whether or not appear adverse short-term outcomes in STEMI patient underwent PCI. Methods Study patients (n = 184, mean 61.5 ± 12.6 years old, male 71.5% ) with STEMI of onset < 12h who underwent primary percutaneous coronary intervention ( PCI) and who had baseline NT-proBNP serum level by ECLIA. The study subjects were divided into two groups according to the serum level of NT-proBNP. Results Patients with NT-proBNP level > 990 pg/ml(n = 76, male 55. 8%) had left ventricle ejection fraction (LVEF)( 47.7±12.2% vs 53.2 ±10.8% ,P<0.001) , need longer intensive care (3.8 ±3.6 vs 2.3 ±2.7days,P< 0.001), and had higher in-hospital mortality (7. 2% vs 1. 3% , P < 0. 001) than those with NT-proBNP level≤990 pg/ml ( n = 108, male 75.2% ). Conclusion This experiment indicated that NT-proBNP serum level is associated with short term mortality in patients with STEMI underwent primary PCI.
关键词
N-端脑钠肽前体/ST段抬高型急性心肌梗死/经皮腔内冠状动脉成形术Key words
N-terminal pro-B type natriuretic peptide( NT-proBNP)/ST-elevated myocardial infarction( STEMI)/percutaneous coronary intervention(PCI)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据