Clinical Significance of Changes on Serum Visceral Protein and Inflammatory Cytokines Levels Both Before and After Chest Operation in Patients with Thoracic Malignant Tumors
Objective To explore the changes of related serum visceral protein and inflammatory mediators levels both before and after chest operation on thoracic malignancies and clinical significance of determination. Methods Serum contents of PRE , Tf, RBP levels were measured with immuno nephelometry and serum IL-6, IL-8 or TNF-α levels with radioimmunoassay both before and after operation on 30 chest operation on thoracic malignant tumors patients as well as in 32 normal persons served as control group. Results The serun levels of these three visceral protein in the patients 24h before operation showed slightly lower, but not significantly higher than those in normal control group(P>0.05), 2h aftery surgery, the serun levels all decreased more and proved significantly differences than that normal control group(all P<0.05) , and serum levels of these three visceral protein expressed decreased farther and by 24h, indicated remarkably differences than the normal control group( all P<0.01). Compared with two groups of operation, and serum levels of three visceral protein decreased farther in 24h postoperatively group than the 2h postoperatively group. The changes of three serum inflammatory medium level results showed, these serum levels of cytokine presented all obviously increased in 2h postoperatively and 24h postoperatively group than those in normal control group(P<0.05, P<0.01) , but these serum level of inflammatory mediators indicated increased more significantly in 24 h after the operation group, but no significant differences higher than those in 2h postoperatively group(P>0.05). Conclusion Stress reaction proved very obvious in these patients perioperative period with significantly higher serum levels of six markers, according to this datas, and to remind the clinical should be fully prepared to deal with a variety of plans in the whole operation period.
NETL
NSTL
万方数据
维普
