Objective To explore the clinical significance of measurement the changes on serum OPN, IL-2 and VEGF levels both before and after treatment in patients with tuberculosis. Methods serum IL-2 (with RIA). Serum OPN, VEGF(with ELISA) levels were determined in 62 patients with tuberculosis both before and after treatment and compared to 35 normal persons as controls. Re-Sults Before treatment. Serum OPN, VEGF levels were significantly higher than those in controls (P<0.01), but serum IL-2 level was obviously lower(P<0.01). After treatment for 2 months the levels changed markedly toward normal, but remained significantly different from those in controls(P<0.05) serum OPN level was negatively correlated with serum IL-2 level(r=-0.4822, P<0.01). while the serum VEGF level was positively correlated(r=0.6134, P<0.01). Conclusion Detection of serum OPN, IL-2 and VEGF levels in patients with active pulmonary tuberculosis can be used as early indicators for assessment of tuberculosis diseases activity and therapeutic efficacy of anti-TB drugs.
NETL
NSTL
万方数据
维普
