Clinical Values of Measurement of Changes on Plasma ET-1 and Serum MMP-2, MMP-9 Levels After Transfusion of Red Blood Cells Suspension in Patients with Nephrotic Syndrome
Objective To explore the changes on plasma ET-1 and serum MMP-2, MMP-9 levels after transfusion of red blood cells suspension in patients with nephrotic syndrome. Methods Plasma ET-1 (with RIA), serum MMP-2, MMP-9 (with ELISA) levels were determined in 32 patients with nephrotic syndrome and compared with 35 normal healthy children served as control. Result Before transfusion, plasma ET-1 and serum MMP-2 levels in the patients were significantly higher than those in controls (P<0.01). But the MMP-9 level showed markedly lower(P<0.01). After a course for 2 weeks transfusion of red blood cells, the levels in patients though dropped notably but still remained higher than those in controls (P<0.05). Conclusion Detection of plasma ET-1 and serum MMP-2, MMP-9 levels after transfusion RBCs suspension might be useful for monitoring progress and prognosis of patients with nephrotic syndrome and possess important clinical values .
NETL
NSTL
维普
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