Objective Discussion on 17-OH, 17-KS, VMA, AID and COR levels in cardiovascular disease and its applicative value. Methods With micro column chromatography and electrochemiluminescence as the method to detecte 24h urine 17-OH, 17-OH, VMA and plasma ALD, serum COR levels in 116 patients with primary hypertension, 52 patients with secondary hypertension and 21 patients with coronary heart disease( CHD),30 cases of healthy people served as the normal control group. Results Compared with the control group, 17-OH, 17-KS, VMA, ALD and COR levels expressed lower in secondary hypertension group than those in the control group and hypertension group; 17-OH, 17-OH and ALD, COR levels showed significantly higher in CHD group than the control group(P<0.01, P<0.05) ; Related experiments show a positive correlation between ALD and urine 17-OH, 17- KS(r =0.502, 0.796, P<0.01) ; and a positive correlation between COR and urine 17-OH, 17-KS(r =0.648,0.584, P<0.01); there is no corns-lation between plasma AID, serum COR and urine VMA(P>0.05). Conclusion Urine 17-OH, 17-KS, VMA, plasma AID, serum COR as the combined detection, it provides important clinical values in differential diagnosis of primary, secondary hypertension for treatment and judging the prognosis of CHD.
NETL
NSTL
维普
万方数据
