The Changes on Serum β-hBD-2, OPN, pro-ADM and NPt Levels in MODS Patients with Post-traumatic Infection
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NETL
NSTL
维普
万方数据
目的:探讨多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)患者的炎症感染病理过程中炎性介质水平的变化.方法:血清人类β防御素-2(human β-defensin-2,β-hBD-2)、骨桥蛋白(osteopontin,OPN)和新蝶呤(neopterin,NPt)采用酶联免疫分析法(ELISA)测定,肾上腺髓质素前体(pro-adrenomedullin,pro-ADM)检测采用化学免疫发光法.结果:四项血清标志物测定结果分别显示,对照组和确诊时组β-hBD-2、OPN、pro-ADM、NPt四种血清炎症介质标志水平均显著高于正常人组(P<0.05,P<0.01),出院前组β-hBD-2、OPN水平显著高于正常人组,另两项指标均与正常人组比较无显著性差异(P均>0.05);同时确诊时组与对照组比较β-hBD-2、OPN、pro-ADM三项指标水平也显著升高(P<0.05,P<0.01),NPt水平患者组呈略高,但无统计学意义(P>0.05);出院前组β-hBD-2、OPN、pro-ADM、NPt四种血清炎症介质标志水平均显著低于确诊时组(P<0.05,P<0.01).结论:MODS患者的炎症感染病理过程中炎性介质水平显著升高,其测定对于临床抗感染治疗提供重要价值.
Objective In order to explore the changes of inflammatory mediators' levels in patients of MODS in inflammatory pathological process. Methods The serum levels of β-hBD-2, OPN, NPt were measured with ELISA, while pro-ADM with chemilumi-nescence immunoassay. Results Four serum markers assay results showed, the controls (trauma patients) and the diagnosis group serum levels of β-hBD-2, OPN, pro-ADM and NPt were significantly higher(P<0.05, P<0.01) than those in the normal group, before discharge the serum levels of β-hBD-2, OPN expressed significantly higher than those in normal. The diagnosis group serum levels of β-hBD-2, OPN and pro-ADM proved obviously higher (P<0.05, P<0.01) than those in the controls, before discharge the serum levels of β-hBD-2, OPN, pro-ADM and NPt presented significantly lower than those in the diagnosis group(P<0.05, P<0.01). Conclusion In patients of MODS with inflammatory infection levels of inflammatory mediators increased significantly in the pathological process, thus the determination of serum items levels provide important clinical values for anti-infective therapy.
NETL
NSTL
维普
万方数据
