Objective To explore the clinical application of Flow-cytometry in uterine cervix carcinoma(UCC) and cervical in-traepithelial neoplasia(CIN). Methods Flow-cytometry was used to analyze the DNA index(DI), proliferation index(PI) and percent of heteroploid in 61 cases UCC,33 cases CINⅡ～Ⅲ, 28 cases GIN Ⅰ and 10 cases normal cervix. Results 1. DI, PI and percentage of aneuploid of CIN Ⅰ ,CINⅡ～Ⅲ and UCC increased gradually. 2. There is no significant deviation between PI of aneuploid UCC and PI of diploid UCC. PI of aneuploid CINⅡ～Ⅲ showed obviously higher than PI of diploid CINⅡ～Ⅲ, PI of aneuploid CIN Ⅰ expressed significant higher than PI of diploid CIN Ⅰ. PI of diploid CINⅡ～Ⅲ proved significant higher than PI of normal cervix. There is no significant difference between PI of diploid CIN Ⅰ and PI of normal cervix. 3. There are specially notable difference of DI, PI and percentage of aneuploid in different histological grades and clinical stages of UCC. Conclusion In aiding diagnosis and forecasting biological behaviour of precancerous lesion of uterine cervix and judging prognosis of cervical malignancies, Flow-cytometry provides important clinical values.
NETL
NSTL
维普
万方数据
