COPD患者治疗前后血清IL-18、D-D和APN检测的临床意义
Clinical Significance of Determination of Changes on Serum IL-18, D-D and APN Levels After Treatment in Patients with Chronic Obstructive Pulmonary Diseases(COPD)
杨义伟1
作者信息
摘要
目的:探讨了COPD患者治疗前后血清IL-18、D-D和APN水平的变化及临床意义.方法:应用酶联法和生化法对40例COPD患者进行了治疗前后血清IL-18、D-D和APN检测,并与35名健康人作比较.结果:COPD患者在治疗前后血清IL-18、D-D和APN水平均非常显著地高于正常人组(P＜0.01),经治疗2周后则与正常人组比较无显著性差异(P＞0.05),且血清IL-18水平与D-D、APN水平呈显著正相关(r=0.5018、0.6134,P＜0.01).结论:检测COPD患者血清IL-18、D-D和APN水平的变化对了解病情、观察疗效和预后判定均具有一定的临床意义.
Abstract
Objective To explore the clinical significance of changes on serum IL-18, D-D and APN levels after treatment in patients with GOPD. Methods Serum IL-18, APN (with ELISA), serum D-D (with biochemistry) levels were determined in 40 patients with COPD and 35 healthy persons served as controls. Results Before treatment, serum IL-18, D-D, and APN levels showed markedly higher than those in controls (P<0.01) , after treatment for 2 weeks, IL-18, D-D, and APN levels proved no much different from those in controls (P >0. 05). Serum IL-18 levels were positive correlated with serum D-D, APN levels(r=0. 5018,0. 6134,P < 0.01). Conduction Changes of serum IL-18,D-D and APN levels monitoring the severity and progress of diseases might be of important clinical values in patients with COPD.
关键词
慢性阻塞性肺疾病/白细胞介素-18/D-二聚体/脂联素Key words
chronic obstructive pulmonary diseases(COPD)/interleukin-18/D-dimer(D-D)/adiponectin(APN)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据