Clinical value of type Ⅳ collagen and Laminin in diagnosis of chronic liver disease
Objective:To clarify the clinical significance of type Ⅳ collagen(Ⅳ·C) and laminin (LN) in diagnosis of hepatic fibrosis.Methods:The present study determined serum content of Ⅳ·C and LN in 83 patients with chronic hepatitis and 23 patients with posthepatitic cirrhosis by radioimmunoassay.Results:Serum level of LN was (145.1±37.9)μg/l，Ⅳ·C (67.6±20)μg/l，in the patients with chronic hepatitis,significantly higher than normal people[LN (115.7±17.3)μg/l、Ⅳ·C (49.7±15)μg/l respectively]；in patients with posthepatitic cirrhosis serum level of LN was (207.0±63.3μg/l)、Ⅳ·C (92.9±28.8)μg/l，statistically significant compared respectively with group chronic hepatitis.The correlative analysis showed that there was positive correlation between LN and Ⅳ·C in patients with posthepatitic cirrhosis (r=0.64).The sensitivity of LN and Ⅳ·C in hepatitic cirrhosis was 82.6% and86.9% respectively.Conclusion:There is greatly clinical significance of Ⅳ·C and LN in assessment of existance and development of hepatic fibrosis in patients with chronic liver disease.
NETL
NSTL
万方数据
维普
