阻塞性睡眠呼吸暂停低通气综合征上气道MRI变化与认知功能障碍的关系
Relationship between magnetic resonance image changes of upper airway and cognitive dysfunction in pa-tient with OSAHS
许清华 1林钱森 1陈杰云 1聂吉林2
作者信息
- 1. 362000 福建,泉州市第一医院影像科
- 2. 410008 长沙,中南大学湘雅医院放射科
- 折叠
摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者上气道 MRI 变化与认知功能障碍的关系.方法:选取 2020 年 11 月-2021 年 12 月中南大学湘雅医院收治的 OSAHS 合并认知功能障碍患者 100 例为观察组,另纳入同期诊断为 OSAHS但未合并认知功能障碍的患者 100 例作为对照组,均完善上气道MRI检查.搜集所有患者的临床及影像资料并筛选影响 OSAHS患者发生认知功能障碍的相关因素,并采用蒙特利尔认知评估量表(MoCA)评估观察组患者的认知功能障碍严重程度.结果:观察组中年龄≥60 岁、合并糖尿病、高血压、高脂血症及冠心病、重度 OSAHS及存在舌咽平面上气道形态异常的人数占比均明显高于对照组(P＜0.05).logistic 回归分析结果显示,年龄≥60岁、合并高血压、糖尿病、冠心病及高脂血症、重度 OSAHS及舌咽平面上气道形态存在异常等均是影响OSAHS患者发生认知功能障碍的风险因素(P＜0.05).重度认知功能障碍组的气道矢径明显低于轻度和中度认知功能障碍组,舌体容积明显高于其他两组,差异均有统计学意义(P＜0.05);三组患者的最小截面积、气道横径及气道侧壁软组织厚度等参数差异无统计学意义(P＞0.05).结论:病情较重、合并糖尿病、高血压、高脂血症、冠心病等基础疾病的 OSAHS患者发生认知功能障碍的风险较大,可通过监测其上气道MRI变化情况进一步预测认知功能障碍的发生.
Abstract
Objective:To explore the relationship between upper airway magnetic resonance ima-ging(MRI)changes and cognitive dysfunction in patients with obstructive sleep apnea-hypopnea syn-drome(OSAHS).Methods:One hundred OSAHS patients with/without cognitive dysfunction who were admitted to Xiangya Hospital of Central South University hospital from November 2020 to De-cember 2021 were enrolled as the observation and control group,respectively.All of them underwent the magnetic resonance imaging of upper airway.The clinical data were collected and the relevant fac-tors influencing the cognitive dysfunction of patients with OSAHS were screened.The severity of cog-nitive dysfunction in the observation group was assessed by Montreal Cognitive Assessment Scale(MoCA).Results:Compared with the control group,the proportion of patients who were≥60 years old,accompanied with diabetes,hypertension,hyperlipidemia and coronary heart disease,severe OS-AHS and the existence of glossopharyngeal plane airway morphology abnormality was significantly higher in the observation group(P＜0.05).The results of logistic regression analysis showed that age≥60 years old,combination of hypertension,diabetes,coronary heart disease and hyperlipidemia,se-vere OSAHS and abnormal morphology of upper glossopharyngeal airway were all risk factors for cognitive dysfunction in OSAHS patients(P＜0.05).The airway sagittal diameter of the severe cogni-tive dysfunction group was significantly lower than that of the mild and moderate cognitive dysfunc-tion group,and the tongue volume was significantly higher than that of the other two groups(P＜0.05).There was no significant difference in parameters such as minimum cross-sectional area,trans-verse diameter of airway,and tongue volume among the three groups(P＞0.05).Conclusion:Severe OSAHS and basic medical history of diabetes,hypertension,hyperlipidemia or coronary heart disease are risk for cognitive dysfunction which can be further predicted by monitoring the changes of upper airway by magnetic resonance imaging.
关键词
阻塞性睡眠呼吸暂停低通气综合征/上气道/磁共振成像/认知功能障碍Key words
Obstructive sleep apnea hypopnea syndrome/Upper airway/Magnetic resonance imaging/Cognitive dysfunction引用本文复制引用
基金项目
福建省卫生健康科技计划相关课题(2020)(2020QNA082)
出版年
2024
NETL
NSTL
维普
万方数据