Brain functional changes in first-episode major depression disorder:low-frequency fluctuation and regio-nal homogeneity analysis based on resting-state fMRI
Brain functional changes in first-episode major depression disorder:low-frequency fluctuation and regio-nal homogeneity analysis based on resting-state fMRI
Objective:To explore the multimodal characteristics of the amplitude of low-frequen-cy fluctuations(ALFF)and regional homogeneity(ReHo)by fMRI in first-episode major depression disorder(MDD),and further clarify the central nervous system theory of depression.To investigate the characteristics of low frequency amplitude and local consistent brain area of resting state fMRI during the first major depressive episode,and further identify the neurological mechanism of depres-sion.Methods:From January 2022 to October 2022,40 cases in the first MDD group diagnosed by the Fourth edition of the Diagnostic and Statistical Manual of Mental Disorders(DSM-IV)and 50 cases in the healthy control group in Guangzhou Red Cross Hospital were included in this study.Each subject received 3.0T resting fMRI and HD T1WI examinations.Two-sample t-test was used to compare the inter-group differences in ALFF and ReHo indexes between the two groups,respectively.Results:There were no significant differences in age and education background between the two groups(P＜0.05).Compared with the healthy control group,the ALFF values of the left inferior temporal gyrus,bilateral thalamus,bilateral middle frontal gyrus and left para-motor area increased in the first MDD group,while the ALFF values of the bilateral posterior central gyrus,left middle temporal gyrus,left middle occipital gyrus,left posterior cingulate gyrus and left anterior cuneus decreased(AlphaSim cor-rection,voxel level P＜0.05,cluster level P＜0.05).The ReHo values of bilateral inferior temporal gy-rus,left insula and bilateral middle frontal gyrus in the first MDD group were higher than those in the control group,while the ReHo values of left middle temporal gyrus,bilateral posterior central gyrus,left middle occipital gyrus and right anterior cuneus were lower than those in the control group(Al-phaSim correction,voxel level P＜0.05,cluster level P＜0.05).The increased ALFF and ReHo values were mainly located in the left inferior temporal gyrus and bilateral medial frontal gyrus,while the de-creased ALFF and ReHo values were located in the left medial temporal gyrus,bilateral posterior cen-tral gyrus and left medial occipital gyrus.Conclusion:There are extensive abnormalities in the sensori-motor network,visual-auditory network,default network and executive control network in first-epi-sode MDD.The results of this study may provide preliminary clues to better understand the occurrence and development of first-episode MDD.
关键词
首发抑郁症/脑功能/功能磁共振成像/低频振幅/局部一致性
Key words
Depression disorder,First-episode/Brain function/Fuctional magnetic resonance imaging/Amplitude of low-frequency fluctuations/Regional homogeneity
维普
万方数据