Objective:To investigate the changes in liver and kidney images during the hepatobil-iary phase of gadoxetate disodium(Gd-EOB-DTPA)enhanced MRI in patients with type 2 diabetes mellitus(T2D).Methods:Eighty-two patients with normal liver and kidney function who underwent abdominal Gd-EOB-DTPA enhanced MRI were collected,including 34 patients with T2D(observation group)and 48 patients without T2D(control group).The relative signal intensity(RI)of the liver in the hepatobiliary phase,the relative SI of the renal cortex and medulla(Rrc and Rrm),and the rela-tive difference in the signal intensity of the renal corticomedulla(Rc-m)during the hepatobiliary pha-ses were calculated respectively by two radiologists.The independent samples t-test or Mann-Whitney U statistic was used to compare the differences in relevant parameters between the observation and control groups.Statistically significant variables were selected,and the receiver operating characteristic(ROC)curve was used to analyze their efficacy in identifying T2D.The intraclass correlation coeffi-cient(ICC)was used to evaluate the reproducibility.Results:RL and Rc-m in the observation group were significantly lower than those in the control group(P＜0.05),and there was no statistically sig-nificant difference for Rrc and Rrm(P＞0.05).The areas under the ROC curves for the identification of T2D by RL and Rc-m were 0.78 and 0.72,respectively.The sensitivity and specificity of RL and Rc-m in differentiating T2D were 77.10％,70.60％and 64.60％,79.40％,respectively.Both RL and Rc-m showed good inter-observer consistency,with ICC of 0.91 and 0.89 for RL and Rc-m,respectively.Con-clusion:The RL and Rc-m of liver and kidney decreased during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI in T2D patients.RL and Rc-m might help to identify T2D under certain condi-tions with good reproducibility.
关键词
2型糖尿病/Gd-EOB-DTPA/磁共振成像/肝脏/肾脏
Key words
Type 2 diabetes/Gd-EOB-DTPA/Magnetic resonance imaging/Liver/Kidney
维普
万方数据