Objective:The aim of this study is to analyze the correlation between inflammatory changes of pericarotid adipose tissue(PCAT)and plaque characteristics using CT angiography(CTA)among patients with H-type hypertension,and to explore the value of head and neck CTA in the pre-vention and treatment of carotid atherosclerosis.Methods:128 patients with carotid atherosclerosis ex-amined by head and neck CTA were retrospectively analyzed and divided into high Hcy group and nor-mal Hcy group according to Hcy value,and then divided into H-type hypertension group,simple hy-pertension group,simple high Hcy group and control group according to the blood pressure.The pa-rameters of plaque characteristics(plaque area,plaque load and remodeling index)and the PCAT at-tenuation values(flattening and enhancing phases)were recorded,and the net enhancement values were calculated.ANOVA was used to compare the differences in PCAT attenuation changes and plaque characteristic parameters between groups,and logistic regression was used to analyze the independent risk factors for plaque vulnerability.Results:The results of the study showed that there was a statisti-cally significant difference between the attenuation and net intensification values during the PCAT en-hancement period in the H-type hypertension group,the high Hcy alone group and the control group(P＜0.05);the vulnerable plaque rate in the H-type hypertension group was statistically different from that in the high Hcy alone group and the control group(P＜0.05);and logistic regression analy-sis showed that H-type hypertension(OR=8.228,95％CI:2.371～28.549,P=0.001),Hcy value(OR=1.183,95％CI:1.049～1.334,P=0.006),degree of luminal stenosis(OR=1.087,95％CI:1.054～1.122,P＜0.001)and net reinforcement(OR=1.205,95％CI:1.101～1.319,P＜0.001)were inde-pendent risk factors for plaque vulnerability.Conclusion:Head and neck CTA has an important role in quantifying plaque characteristics and PCAT attenuation.H-type hypertension,Hcy values,luminal stenosis and net PCAT enhancement values are independent risk factors for assessing plaque vulnerability.
维普
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