Objective:To explore the differences in clinical and CT features of pulmonary crypto-coccosis(PC)patients with and without cryptococcal meningitis(CM),and to identify additional early warning indicators for the diagnosis of CM.Methods:A total of 87 patients with PC confirmed by lung biopsy or surgical resection in our hospital from January 2014 to June 2022 were retrospectively en-rolled in this study.Among them,38 cases were combined with CM(meningitis group)and 49 cases were not combined with CM(control group),and the clinical and CT features between the two groups were compared.Results:The incidence of history of immune function impairment,decreased CD4+T cells proportion and decreased CD4+/CD8+ T cells ratio in meningitis group were significantly higher than those in the control group(all P＜0.05).There were no statistically significant differences in the age,gender,smoking history and the incidence of decreased CD3+and CD8+T cells proportion be-tween the two groups(all P＞0.05).The incidence of cavity and intrathoracic lymph node enlargement were significantly higher in the meningitis group than in the control group,while the incidence of halo sign and air bronchogram were significantly lower in the meningitis group than in the control group(all P＜0.05).There were no statistically significant differences in the distribution of lesions,CT stag-ing,number of lesions,spiculation,lobulation,pleural retraction and the presence of pleural effusion between the two groups(all P＞0.05).Conclusion:The clinical and CT features between PC patients with and without CM were different.Patients with PC who have a history of immune function impair-ment,abnormal cellular immune function,presence of cavity but absence of halo sign and air bron-chogram,and enlargement of intrathoracic lymph nodes were susceptible to develop CM.Our research can help screen these patients earlier,adjust the treatment timely,and improve the prognosis.
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