Assessment of left ventricular myocardial injury in patients with hypertrophic cardiomyopathy combined with T2 high signal based on cardiac magnetic resonance feature-tracking technique
Assessment of left ventricular myocardial injury in patients with hypertrophic cardiomyopathy combined with T2 high signal based on cardiac magnetic resonance feature-tracking technique
Objective:To evaluate the damage of left ventricular myocardial in hypertrophic car-diomyopathy(HCM)combined with T2 high signal using cardiac magnetic resonance tissue tracking(CMR-FT),and to investigate the correlation between serum myocardial enzymatic indices and T2 high signal in the myocardium.Methods:A total of 50 patients with HCM were retrospectively includ-ed,and the HCM patients were divided into the HCM-T2(+)group(n=20)and the HCM-T2(-)group(n=30)according to whether they had combined with T2 high signal;according to whether tro-ponin was elevated or not,the group with elevated troponin[cTnI(+)group]and the group with normal troponin[cTnI(-)group]were divided;and 26 people without significant cardiovascular dis-ease were collected as controls during the same period.The differences in global longitudinal strain(GLS),global circumferential strain(GCS)and global radial strain(GRS)of LV strain by cardiac magnetic resonance were compared between the above groups;and ROC curves were plotted to evalu-ate the ability of myocardial injury markers to diagnose T2 high signal in the myocardium.Results:Left ventricular GLS,GCS and GRS were all lower in the HCM group compared to healthy controls(P＜0.05).Further analysis suggested that left ventricular GLS,GCS and GRS were lower in the HCM-T2(+)group compared to the HCM-T2(-)group(all P＜0.05).The GRS was significantly lower in the cTnI(+)group compared with the cTnI(-)group(P＜0.05),and the elevation of troponin in serum was valuable in predicting the occurrence of T2 high signal in the myocardium.Conclusion:There is an impairment in overall LV strain in patients with HCM,with more pronounced strain impairment in patients with HCM with focal myocardial oedema.Elevated troponin in serum implies more severe myocardial injury in HCM patients,and elevated troponin in the serum of HCM patients can be used to suggest the presence of focal myocardial edema in HCM patients.
关键词
肥厚型心肌病/心脏磁共振/心肌应变/心肌水肿/肌钙蛋白
Key words
Hypertrophic cardiomyopathy/Cardiovascular magnetic resonance/Myocardial strain/Myocardial edema/Troponin
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