Objective:To quantitatively evaluate the impact of comorbid type 2 diabetes mellitus(T2DM)on left ventricular myocardial strain and tissue characterizations in nonischemic dilated car-diomyopathy(NIDCM)patients by cardiac magnetic resonance feature tracking(CMR-FT)and late gadolinium enhancement(LGE).Methods:Thirty-eight NIDCM patients and 20 healthy controls who underwent CMR examination were retrospectively included.NIDCM was divided into two groups ac-cording to the history of T2DM.The general clinical data,left ventricular structure,function,strain pa-rameters were compared among the three groups and tissue characterization between the two NIDCM groups.Clinical important predictors of left ventricular myocardial strain in patients with NIDCM were analyzed by simple linear regression analysis.Results:The prevalence rates of hypertension and the HbA1c level in the NIDCM(T2DM+)group were significantly higher than those in the NIDCM(T2DM-)group and the control group(both P＜0.05).The apical circumferential strain(CS)and longitudinal strain(LS),global CS in NIDCM(T2DM+)group were significantly lower than those in NIDCM(T2DM-)group(all P＜0.05).However,there was no significant difference in the LGE characteristics between the two NIDCM groups.In univariable linear regression analysis T2DM was an significant predictor of the reduced left ventricle global CS(β=0.35,P=0.031)and LS(β=0.354,P=0.029)in NIDCM patients.Conclusion:CMR-FT can accurately assess the deterioration of left ven-tricular myocardial strain in NIDCM patients with T2DM.And T2DM was significantly associated with the reduced left ventricular global CS and LS in NIDCM patients.
维普
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