基于MRI扩散张量成像的腰骶丛神经定量研究
Quantification of lumbosacral plexus by diffusion tensor imaging
钱贵珍 1黄家荣 1汪梅 1李玥 1徐建 1苗重昌1
作者信息
- 1. 222002 江苏,徐州医科大学附属连云港医院影像科
- 折叠
摘要
目的:探讨影响正常人腰骶丛神经扩散张量成像(DTI)参数值相关临床基线资料,获得腰骶丛神经各向异性分数(FA)、表观扩散系数(ADC)、轴向扩散系数(AD)和径向扩散系数(RD)正常值参考范围.方法:前瞻性搜集60名健康志愿者,年龄平均在20～80岁之间,所有受试者接受3.0T MR扫描,包括DTI和3D-T2W-FFE序列,由两名医师独立测量腰骶丛L4-S1双侧共360条神经根椎管内、椎间孔内及椎间孔外3个ROI的DTI参数值,计算平均值.采用Pearson相关分析检验DTI参数值与临床基线资料相关性,对与多个临床基线资料相关的DTI参数进行多元线性回归分析.结果:正常人腰骶丛神经FA、ADC、RD、AD值在左右两侧及L4-S1组间差异无统计学意义.平均FA值与年龄(r=-0.687,P＜0.001)、体重(r=-0.411,P=0.001)、BMI(r=-0.378,P=0.003)存在负相关性,平均RD值与年龄(r=0.293,P=0.023)存在正相关性.构建关于腰骶丛神经FA值的多元线性回归模型,将与FA值相关变量以逐步法代入,最终年龄和体重作为预测变量,得出FA值的多元线性回归模型,调整后R2=0.620,进一步提出校正公式以根据年龄和体重调整FA值.结论:腰骶丛FA值随着年龄和体重增加而下降,提示涉及腰骶丛DTI研究中考虑年龄和体重因素.
Abstract
Objective:To explore relationship between the clinical baseline data and diffusion tensor imaging(DTI)-derived indices of lumbosacral plexus in normal population and obtain the refer-ence range for normal values of lumbosacral plexus anisotropy fraction(FA),apparent diffusion coef-ficient(ADC),axial diffusion coefficient(AD)and radial diffusion coefficient(RD).Methods:A total of sixty healthy volunteers aged 20～80 years were prospectively enrolled.Two physicians independ-ently measured the DTI parameters of three ROIs in the spinal canal,intervertebral foramen,and out-side the intervertebral foramen of 360 nerve roots on both sides of the lumbosacral plexus(L4-S1)and calculated the average values.Pearson correlation was used to evaluate the correlation between DTI parameter values and clinical baseline data,and multiple linear regression analysis was performed on parameters related to multiple clinical baseline data.Results:The difference were not significant be-tween were not significantly between the left and right sides and between L4-S1 groups for FA,ADC,RD,AD of the lumbosacral plexus in normal people.The average FA value was negatively corre-lated with age(r=-0.687,P＜0.001,body weight(r=-0.411,P=0.001),BMI(r=-0.378,P=0.003).To construct a multiple linear regression model for lumbosacral plexus FA values,the variables related to FA value were selected by the stepwise method.The final model used age and body weight as predictive variables,resulting in an adjusted R2 of 0.620.A correction formula was provided to adjust FA values according to age and body weight.Conclusion:The FA of the lumbosacral plexus decreases with age and weight,suggesting that these factors should be considered in the study of lumbosacral plexus DTI.
关键词
磁共振成像/腰骶丛/年龄/定量评价Key words
Magnetic resonance imaging/Lumbosacral plexus/Aging/Quantitative evaluation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据