Clinical value of MAGnetic resonance image compilation(MAGiC)for differentiating benign and malignant lesions of PI-RADS 3 in transitional zone of prostate
Objective:To investigate the clinical value of MAGiC technique in differentiating be-nign and malignant lesions of PI-RADS 3 in the transition zone of the prostate.Methods:134 patients with 134 PI-RADS 3 lesions in transitional zone of prostate were included retrospectively.We measured and compared the MAGiC quantitative parameters(T1,T2 and PD values)between different PI-RADS 3 lesions in the transition zone of the prostate(prostate cancer and prostatic benign hyperplasi-a),and observed the optimal diagnostic cut-off value,sensitivity,specificity,PPV,NPV,95％CI and Youden index of these three quantitative parameters in PCa diagnosis.Results:In PI-RADS 3 lesions in transition zone of prostate,the T1,T2,and PD values of PCa were(1171.86±25.75)ms,(74.41±1.13)ms,and(66.16±1.45)pu,respectively,which were lower than those of benign hyperplasia lesions.The AUC values of T1,T2,and PD values diagnosing PCa in PI-RADS 3 lesions in transition zone of pros-tate were 0.617,0.820,and 0.549,respectively.The sensitivity,specificity,PPV,and NPV were 47.06％,83.13％,63.20％,and 71.90％for T1 value,76.47％,80.72％,70.90％,and 84.8％for T2 val-ue,and 47.06％,85.54％,66.70％,and 72.40％for PD value,respectively.The 95％confidence interval were 0.529～0.700,0.745～0.881 and 0.460～0.635,respectively.The Youden index were 0.302,0.572,and 0.326,respectively.The optimal diagnostic cut-off value of the T2 value was 77ms.Conclusion:The T2 value of MAGiC technique can quantitatively predict the benign and malignant lesions of PI-RADS 3 lesions in the transition zone of the prostate,which can reduce unnecessary puncture biopsy.
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