Objective:To investigate whether the pathophysiological mechanism of white matter hyperintensities(WMH)and its penumbra(WMH-P)is associated with the change of interstitial flu-id content and whether there is pathological cascade reaction.Methods:Seventy-eight patients with non-dementia cerebrovascular disease(CSVD)underwent 3.0T MRI scanning,including T1WI,FLAIR and diffusion kurtosis imaging(DKI).The DKI parameters'values of deep and periventricular WMH,the innermost layer to outermost layer of normal-appearing white matter(NAWM)mask layer(NAWM-L1 to NAWM-L15),and the whole brain NAWM region were measured.By determining the WMH-P range of each DKI parameter,the abnormal range of diffusivity and diffusion kurtosis values in WMH and WMH-P were compared,the relationship between the values of DKI parameters in WMH and WMH-P was explored,and the difference of liquid content in interstitial and the relationship between different microstructure were evaluated.Results:The WMH-P ranges defined by AD,MD,RD,AK,MK,RK and FA are NAWM-L9,NAWM-L6,NAWM-L5,NAWM-L6,NAWM-L3,NAWM-L3 and NAWM-L3,respectively.There were correlations among DKI parameters in the outer edge of WMH to NAWM-L9,and the correlation between MD and RD was strongest(r=-0.989,P＜0.01).The values of AD,AK,MD,RD,and FA were correlated with MK value(r=-0.703;0.653;-0.802;-0.818;0.744;P＜0.01)and RK value(r=-0.523;0.364;-0.656;-0.692;P＜0.01)was found only in WMH and WMH-P.The correlation between AD value and FA value(r=-0.527,P＜0.01)was found only in WMH and WMH-P.Conclusion:The range of WMH-P of diffusivity is wider than that of diffusion kurtosis,and there is a correlation between some DKI parameters in WMH and WMH-P.It suggested that the pathophysiological mechanism of WMH and WMH-P may be associated with the change of interstitial fluid content,and there may be pathological cascade reaction between interstitial fluid content and different microstructure.
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