Objective:To explore the relationship between glymphatic system function and cog-nitive function in patients with cerebral small vessel disease(CSVD).Methods:Seventy patients with CSVD and 37 healthy controls(HCs)were prospectively collected.Diffusion tensor imaging(DTI)a-nalysis along the perivascular space(ALPS index)was applied to characterize glymphatic function.ALPS index among the HCs group,CSVD-normal cognition group(CSVD-CN),and CSVD-impaired cognition group(CSVD-CI)were compared.Spearman correlation analysis and logistic regression a-nalysis were used to evaluate the relationship between ALPS index and cognitive function in patients with CSVD.Results:The left ALPS index,right ALPS index,and bilateral average ALPS index of the CSVD-CI group were significantly lower than those of the CSVD-CN group and HCs group(P＜0.017,bonferroni correction).The bilateral average ALPS index of CSVD patients was positively corre-lated with MoCA score(ρ=0.583,P＜0.001),visual space and executive function(ρ=0.285,P=0.017),attention(ρ=0.301,P=0.011),delayed memory(ρ=0.697,P＜0.001),and directional ability(ρ=0.329,P=0.006).The lower bilateral average ALPS index could significantly increase the risk of cognitive impairment,and it was an independent risk factor for overall cognitive impairment in CSVD patients[after adjusting for confounding factors,OR=3.674,95％CI(1.017～13.273),P=0.047].Conclusion:Patients with CSVD had glymphatic dysfunction.The overall declined glymphatic function is an independent risk factor for cognitive impairment in patients with CSVD.
Cerebral small vascular diseaseGlymphatic systemDiffusion tensor imagingCognitive impairment
NETL
NSTL
万方数据
