基于MRI的直方图分析评估多发性骨髓瘤治疗反应
MRI-based histogram analysis for treatment response assessment in patients with multiple myeloma
张雨柔 1朱心雨 1郭立 1黄鹏1
作者信息
- 1. 650106 昆明,昆明医科大学第二附属医院放射科
- 折叠
摘要
目的:探究基于磁共振成像的直方图分析评价多发性骨髓瘤治疗反应的价值.方法:将47例经血液学和组织学证实的多发性骨髓瘤患者根据IMWG标准分为反应良好组和反应不良组.收集两组间治疗前的临床基线数据和治疗前后的T1WI、T2WI和STIR图像,并将图像导入MaZda软件提取两组的直方图参数.最后将直方图参判别效能与人工判别结果进行比较.结果:反应良好组与反应不良组治疗前基线数据和直方图参数差异均无统计学意义.反应良好组治疗后T1WI、T2WI两个序列的Perc.99％、Perc.90％、Perc.50％、变异度和均值以及STIR序列的峰度和偏度于治疗后数值升高,而T1WI序列的峰度和偏度于治疗后数值降低.反应不良组T1WI序列的Perc.1％和Perc.10％治疗后数值升高,STIR序列的Perc.1％治疗后数值降低.直方图参数评估效能优于人工判别.结论:基于磁共振成像的直方图分析,可用于影像客观评估MM治疗反应,有助于多发性骨髓瘤治疗反应的初步评价.
Abstract
Objective:To investigate the value of magnetic resonance imaging(MRI)-based his-togram analysis in the evaluation of treatment response for multiple myeloma.Methods:47 patients with hematologically and histologically confirmed multiple myeloma were included and divided into good response and poor response groups according to IMWG criteria.Pre-treatment clinical baseline data and pre-and post-treatment T1WI,T2WI,and STIR images were collected and imported into MaZda software to extract histogram parameters for both groups.Finally,the histogram parametric discrimination efficacy was compared with the manual discrimination results.Results:The differences in pre-treatment baseline data and histogram parameters between the good and poor response groups were not statistically significant.Perc.99％,Perc.90％,Perc.50％,variability and mean,and Kurtosis and Skewness of the STIR sequence of the two sequences of T1WI and T2WI in the good response group increased in value after treatment,while the Kurtosis and Skewness of the T]WI sequence were decreased in value after treatment.Perc.1％and Perc.10％values of T1WI sequences in the poor re-sponse group were elevated after treatment,and Perc.1％values of STIR sequences were decreased af-ter treatment.The histogram parameters evaluation efficacy was better than manual discrimination.Conclusion:MRI-based histogram analysis can be used for imaging objective assessment of treatment response in multiple myeloma,and can contribute to the initial evaluation of treatment response.
关键词
磁共振成像/直方图分析/多发性骨髓瘤/治疗反应Key words
Magnetic resonance imaging/Histogram analysis/Multiple myeloma/Treatment response引用本文复制引用
基金项目
云南省卫生健康委员会医学学科带头人培养计划(D-2019024)
出版年
2024
NETL
NSTL
万方数据