Objective:To investigate the changes of glymphatic system function in male patients with autism spectrum disorder(ASD)aged 9～18 years using diffusion tensor image analysis along the perivascular space(DTI-ALPS),and to explore the relationship between the DTI-ALPS index and clinical manifestations.Methods:A total of 34 male participants aged 9～18 years meeting the diagnos-tic criteria for ASD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edi-tion(DSM-5)and 30 age-matched male typically developing controls were enrolled at Peking Univer-sity Sixth Hospital.All participants underwent diffusion tensor imaging(DTI),and the along perivas-cular space(ALPS)index was calculated.The differences in clinical data and bilateral ALPS index(ALPS-L,ALPS-R)among the two groups were compared,and the correlations between bilateral ALPS index and social responsiveness scale(SRS)in all participants were analyzed.Results:Compared with the control group,the ASD group showed significantly lower ALPS index in bilateral cerebral hemispheres(ALPS-L:t=2.060,P=0.044;ALPS-R:t=2.675,P=0.010).There was no significant correlation between the overall ALPS-L and SRS scores(P＞0.05),and there was no significant corre-lation between the overall ALPS-R and SRS scores for social cognition,social communication,and so-cial motivation(P＞0.05).However,there was a negative correlation between the overall ALPS-R and SRS scores for social awareness,autistic mannerisms,and total score(r=-0.309,P=0.013;r=-0.359,P=0.004;r=-0.298,P=0.017).Conclusion:Patients with ASD have glymphatic system dysfunction,which is related to clinical symptoms of ASD and may be one of the underlying pathologi-cal bases of ASD.
万方数据
维普
